Tag: Viral Genetics and Evolution

Genetic Testing in Men With mCRPC

AI SummaryThis study examines the use of genetic testing for homologous recombination repair mutations in men with metastatic castration-resistant prostate cancer (mCRPC). It aims to identify characteristics associated with this testing in order to better understand its role in this population. The findings could have implications for personalized treatment approaches and outcomes for men with… Continue reading Genetic Testing in Men With mCRPC

Data-driven recombination detection in viral genomes

AI Summaryand drug resistance. The ability to accurately detect recombination events in viral genomes is crucial for understanding viral evolution, transmission dynamics, and vaccine design. The proposed method, RecombinHunt, demonstrates high accuracy, specificity, and sensitivity in identifying recombinant genomes in SARS-CoV-2 and other viruses, showing promising potential for application in tracking and studying viral epidemics… Continue reading Data-driven recombination detection in viral genomes

Recombination analysis on the receptor switching event of MERS-CoV and its close relatives: implications for the emergence of MERS-CoV

AI SummaryThis article discusses recombination analysis on the receptor switching event of MERS-CoV and its close relatives. The study focuses on understanding the emergence of MERS-CoV and its relationship with other viruses within the subgenus Merbecovirus. The research aims to provide insights into the genetic mechanisms underlying the evolution of MERS-CoV and its potential implications… Continue reading Recombination analysis on the receptor switching event of MERS-CoV and its close relatives: implications for the emergence of MERS-CoV

P12.11 RECQL4 promotes immune evasion and limits response to anti-PD-1 therapy and survival in melanoma patients

AI SummaryThe article explores the impact of RECQL4, a DNA helicase, on melanoma progression and the efficacy of immune checkpoint inhibitor therapy. RECQL4 amplification downregulates immune-related pathways, promotes immune evasion, and correlates with reduced intratumoral immune cell numbers. High RECQL4 expression also serves as an independent prognostic factor for decreased survival and response to anti-PD-1… Continue reading P12.11 RECQL4 promotes immune evasion and limits response to anti-PD-1 therapy and survival in melanoma patients

Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex

AI SummaryThe article explores the use of transcranial low-intensity focused ultrasound stimulation to induce long-term depression of thalamocortical synapses in the adult visual cortex. The study demonstrates that this technique can modulate neuronal activity with high spatial resolution and lead to synaptic changes in deep brain structures. These findings suggest that noninvasive ultrasound stimulation has… Continue reading Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex