Abstract Background LIGHT (oLaparib In HRD-Grouped Tumor types; NCT02983799) prospectively evaluated olaparib treatment in patients with platinum-sensitive relapsed ovarian cancer (PSROC) assigned to cohorts by known BRCA mutation (BRCAm) and homologous recombination deficiency (HRD) status: germline BRCAm (gBRCAm), somatic BRCAm (sBRCAm), HRD-positive non-BRCAm, and HRD-negative. At the primary analysis, olaparib treatment demonstrated activity across all… Continue reading Olaparib as treatment for platinum‐sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency: Phase 2 LIGHT study final overall survival analysis
Tag: Viral Genetics and Evolution
Full-length genome reveals genetic diversity and extensive recombination patterns of Saudi GI-1 and GI-23 genotypes of infectious bronchitis virus
Despite numerous genetic studies on Infectious Bronchitis Virus (IBV), many strains from the Middle East remain misclassified or unclassified. Genotype 1 (GI-1) is found globally, while genotype 23 (GI-23) has… Continue reading on BioMed Central
Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells
PEDV is a highly contagious enteric pathogen that can cause severe diarrhea and death in neonatal pigs. Despite extensive research, the molecular mechanisms of host’s response to PEDV infection remain unclear…. Continue reading on BioMed Central
[ASAP] In-Cage Recombination Facilitates the Enantioselective Organocatalytic [1,2]-Rearrangement of Allylic Ammonium Ylides
Tracking cryptic SARS-CoV-2 hospital outbreak through quasispecies analysis
Since the beginning of the pandemic, contact tracing has been one of the most relevant issues to understand SARS-CoV-2 transmission dynamics and, in this context, the analysis of quasispecies may turn out to b… Continue reading on BioMed Central
Inactivation of checkpoint kinase 1 (Chk1) during parvovirus minute virus of mice (MVM) infection inhibits cellular homologous recombination repair and facilitates viral genome replication
Recombination across distant coronavirid species and genera is a rare event with distinct genomic features
Quasispecies theory and emerging viruses: challenges and applications
Abstract Quasispecies theory revolutionized our understanding of viral evolution by describing viruses as dynamic populations of genetically diverse variants constantly adapting. This article explores the theory’s role in virus-host interactions, including immune evasion, drug resistance, and viral emergence. We review the original model, recent advances, and key virus dynamics needing incorporation into quasispecies theory. We… Continue reading Quasispecies theory and emerging viruses: challenges and applications
347 Highly multiplexed engineering of immune effector cells for advanced cancer therapies
Background To address the challenges of advanced cancers using cellular immunotherapy, it will likely require cutting-edge, multiplex genome engineered immune effector cells. Fortuitously, the development of ‘digital editors’, such as base editors (BEs), have enabled multiplex editing without induction of double strand breaks (DSBs) or need for a DNA donor to install gain- or loss-of-function… Continue reading 347 Highly multiplexed engineering of immune effector cells for advanced cancer therapies
1392 Immune infiltration is associated with improved survival in primary, advanced-stage p53-abnormal endometrial carcinoma
Background Our group and others previously demonstrated that endometrial carcinoma (EC) is comprised of four molecular subtypes that are biologically distinct, diagnostically reproducible, and highly significantly prognostic. Among these subtypes, p53 abnormal (p53abn) EC is by far the deadliest, with over 50% of patients succumbing to disease within 5 years. Recent clinical trials demonstrated that… Continue reading 1392 Immune infiltration is associated with improved survival in primary, advanced-stage p53-abnormal endometrial carcinoma