Abstract Background Magnetic resonance imaging (MRI)-targeted prostate biopsy (MRI-biopsy) detects high-Grade Group (GG) prostate cancers not identified by systematic biopsy (S-biopsy). However, questions have been raised whether cancers detected by MRI-biopsy and S-biopsy, grade-for-grade, are of equivalent oncologic risk. The authors evaluated the relative oncologic risk of GG diagnosed by S-biopsy and MRI-biopsy. Methods This… Continue reading The oncologic risk of magnetic resonance imaging‐targeted and systematic cores in patients treated with radical prostatectomy
Tag: Vaccines and Immunization
The oncologic risk of magnetic resonance imaging‐targeted and systematic cores in patients treated with radical prostatectomy
MRI-biopsy detects high-Grade Group (GG) prostate cancers not identified by systematic biopsy . The authors evaluated relative oncologic risk of cancers diagnosed by MRI and S-Biopsy in a retrospective analysis of patients at Memorial Sloan Kettering Cancer Center . If grade was discordant between biopsies, then the risk was intermediate between grades. For example, the… Continue reading The oncologic risk of magnetic resonance imaging‐targeted and systematic cores in patients treated with radical prostatectomy
Therapeutic Modalities and Clinical Outcomes in a Large Cohort with LRBA Deficiency and CTLA4 Insufficiency
Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
Abstract Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an ongoing research area that started before these versatile nanoparticles were successfully used as COVID-19 vaccines. Currently, efforts are underway to harness this platform for oncology therapeutics, mainly focusing on cancer vaccines targeting multiple neoantigens or direct intratumoural injections of mRNA–LNPs encoding pro-inflammatory… Continue reading Targeting cancer with mRNA–lipid nanoparticles: key considerations and future prospects
A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
Anderson TK, Chang J, Arendsee ZW, Venkatesh D, Souza CK, Kimble JB, et al. Swine influenza A viruses and the tangled relationship with humans. Cold Spring Harb Perspect Med. 2021;11:a038737. Article PubMed PubMed Central Google Scholar Nelson MI, Schaefer R, Gava D, Cantão ME, Ciacci-Zanella JR. Influenza A viruses of human origin in swine. Brazil… Continue reading A polyvalent virosomal influenza vaccine induces broad cellular and humoral immunity in pigs
Alt-RNAtive vaccines elicit anti-malarial TRM cells
Malaria is a vector-borne disease caused by Plasmodium parasites. In an exciting new study, Ganley et al. harness the power of mRNA vaccines to summon tissue-resident memory T cells to battle the parasite as it replicates in the liver. Malaria is a vector-borne disease caused by Plasmodium parasites. As an infected female Anopheles mosquito takes… Continue reading Alt-RNAtive vaccines elicit anti-malarial TRM cells
TWiV 1035: Poxvirus wars, warp speed COVID-19 vaccine rollout
TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity, and discovery of a novel cellular defense comprising a nuclease that is activated by poxvirus infection and cleaves a specific tRNA molecule to inhibit protein synthesis. .… Continue reading TWiV 1035: Poxvirus wars, warp speed COVID-19 vaccine rollout
CTLA-4 blockade induces CD4+ T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma
Immunotherapies against glioblastoma exhibit limited efficacy. Chen et al. examine the impact of immunotherapy in mesenchymal glioblastomas and find that αCTLA-4 treatment promotes tumor suppression in a manner dependent on CD4+ T cells. Mechanistically, microglia serve as essential MHC-II antigen-presenting cells that sustain anti-tumor IFNγ+ CD4+ T cells, which in turn stimulate microglial phagocytic function via AXL-MER signaling.
A universal influenza vaccine – how does it work?
The study aims to investigate the safety, immunogenicity, and potential efficacy of OVX836 at different doses . Vaccine demonstrated an observed protection level of 84%, which was further corroborated by a pooled analysis . The findings are particularly encouraging, as they approach the target efficacy for a universal influenza vaccine (>75%)
H3K4 trimethylation regulates cancer immunity: a promising therapeutic target in combination with immunotherapy
Histone H3 lysine 4 trimethylation (H3K4me3) is a pivotal epigenetic modification in cancer immunity regulation . It is deeply involved in modulating tumor immunogenicity, reshaping tumor immune microenvironment, and regulating immune cell functions .