AI SummaryThe Albert Einstein College of Medicine has received funding from the NIH for a five-year project to develop vaccines and antibody-based therapies against emerging viruses. The project aims to build on lessons learned from COVID-19 by creating a base of critical knowledge about groups of similar viruses, allowing for the rapid development of specific… Continue reading NIH funds new research to combat emerging viruses
Tag: Vaccines and Immunization
Evolution of vaccine adjuvants from empirical discovery to rational design
AI Summarythe evolution towards rational design emphasizes a multifaceted approach that considers both the innate and adaptive immune response, as well as the structural and functional components of adjuvants. This intersection between immunology and medicinal chemistry allows for the optimization of adjuvants to enhance vaccine efficacy and safety. The utilization of advanced techniques and methodologies… Continue reading Evolution of vaccine adjuvants from empirical discovery to rational design
ENGOT-en11/GOG-3053/KEYNOTE-B21: A Randomised, Double-Blind, Phase 3 Study of Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy in Patients With Newly Diagnosed, High-Risk Endometrial Cancer
AI SummaryThis study focuses on the use of pembrolizumab in combination with adjuvant chemotherapy in patients with newly diagnosed, high-risk endometrial cancer. The research aims to evaluate the potential benefits of this treatment approach in patients without residual macroscopic disease post-surgery. Previous findings show that pembrolizumab plus chemotherapy can be beneficial for advanced endometrial cancer,… Continue reading ENGOT-en11/GOG-3053/KEYNOTE-B21: A Randomised, Double-Blind, Phase 3 Study of Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy in Patients With Newly Diagnosed, High-Risk Endometrial Cancer
Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
AI SummaryIn a Phase 1 trial, an experimental mRNA cancer vaccine (mRNA-4359) has shown promise in patients with advanced solid cancers such as lung cancer and melanoma. Nineteen patients received between one and nine doses of the vaccine, which created an immune response against cancer. Adverse events were generally mild, including fatigue, injection site pain,… Continue reading Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
‘Encouraging’ Early Data for mRNA Vaccine in Glioblastoma
AI SummaryThis article discusses promising early data from the first-in-human trial of an mRNA-based cancer vaccine for glioblastoma. Additionally, early results from two other trials presented at ESMO are mentioned, indicating potential advancements in cancer treatment.Results from the first-in-human trial of a new mRNA-based cancer vaccine are promising, as are early results from two other… Continue reading ‘Encouraging’ Early Data for mRNA Vaccine in Glioblastoma
New vaccine candidate shows promise for protecting against Lassa fever
AI SummaryThe article discusses a new vaccine candidate called LASSARAB, developed by researchers, which shows promise in protecting against Lassa fever. LASSARAB is a deactivated or killed vaccine that effectively prevents severe cases of the disease and death in preclinical animal models. This vaccine has an advantage over other Lassa fever vaccine platforms that are… Continue reading New vaccine candidate shows promise for protecting against Lassa fever
Researchers develop promising Lassa fever vaccine
AI SummaryThe research discusses the development of a promising Lassa fever vaccine that has shown potential in preventing severe disease and death in animals. This is significant as Lassa fever is a deadly viral hemorrhagic fever that affects humans in West Africa, and the development of an effective vaccine could help in preventing outbreaks and… Continue reading Researchers develop promising Lassa fever vaccine
Using a molecular scissors to improve CAR-T cell therapy
AI SummaryResearchers have identified a new reason why CAR-T cell therapy fails in some cancer patients and are utilizing molecular scissors to improve the treatment’s outcomes. This discovery is leading to new strategies involving antibodies and gene editing to enhance the effectiveness of CAR-T cell therapy for patients.Researchers mined the molecular foundations of cancer and… Continue reading Using a molecular scissors to improve CAR-T cell therapy
Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
AI SummaryThis article discusses the use of combinatorial innate immunotherapy to overcome resistance within the Ewing sarcoma microenvironment. The study shows that a chimeric antigen receptor (CAR) NK cell targeting MCAM, combined with NKTR-255 (IL-15 agonist) and Magrolimab (CD47 blockade), significantly enhances NK cell cytotoxicity and macrophage phagocytic activity against ES cells. Results from in… Continue reading Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus
AI SummaryThe content describes the discovery of a human endogenous retrovirus (CT-RCC HERV-E) selectively expressed in clear cell renal cell carcinomas (ccRCC) and its use as an antigen for T cell-mediated killing. A novel T cell receptor (TCR) targeting a CT-RCC HERV-E-derived antigen specific to ccRCC was cloned and characterized for its antitumor activity. T… Continue reading Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus