AI Summarythe nucleocapsid structure, providing detailed insights into how the virus replicates and evades the host immune response. This breakthrough in imaging technology could lead to the development of a universal antiviral that targets the nucleocapsid structure, offering hope for combatting multiple filoviruses, including Ebola and Marburg. At this moment, the world has few tools… Continue reading LJI breakthrough offers hope for universal antiviral against filoviruses
Tag: Vaccines and Immunization
Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design
AI SummaryThis study investigates the longitudinal proteome-wide antibody profile in survivors of Marburg virus infection, identifying immunogens in the wing domain that could be key for vaccine design. The research reveals the diversity of antibody responses, persistence of antibodies against specific viral proteins for up to 5 years post-exposure, and the importance of IgG-Fc receptor… Continue reading Longitudinal proteome-wide antibody profiling in Marburg virus survivors identifies wing domain immunogen for vaccine design
Machine learning powers discovery of new cryoprotectants for cold storage
Nature Communications (2024). DOI: 10.1038/s41467-024-52266-w”> Datasets and data-driven approaches. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52266-w Scientists from the University of Warwick and the University of Manchester have developed a cutting-edge computational framework that enhances the safe freezing of medicines and vaccines. Treatments such as vaccines, fertility materials, blood donations, and cancer therapies often require rapid… Continue reading Machine learning powers discovery of new cryoprotectants for cold storage
Survival benefit of adjuvant chemotherapy based on molecular residual disease detection in resected colorectal liver metastases: Subgroup analysis from CIRCULATE-Japan GALAXY
AI SummaryThe article discusses the use of circulating-tumor DNA (ctDNA)-based molecular residual disease (MRD) detection in patients with colorectal liver metastases (CLM). The study aims to explore the survival benefit of adjuvant chemotherapy (ACT) in this patient population after surgical resection. This research could potentially provide valuable insights into risk-stratification and treatment options for individuals… Continue reading Survival benefit of adjuvant chemotherapy based on molecular residual disease detection in resected colorectal liver metastases: Subgroup analysis from CIRCULATE-Japan GALAXY
Osimertinib after definitive chemoradiotherapy in unresectable stage III epidermal growth factor receptor-mutated non-small-cell lung cancer: analyses of central nervous system efficacy and distant progression from the phase III LAURA study☆
AI SummaryThis study focuses on the use of Osimertinib, a third-generation EGFR-tyrosine kinase inhibitor, after definitive chemoradiotherapy in unresectable stage III EGFR-mutated non-small-cell lung cancer. The research analyzes the drug’s efficacy in preventing distant progression, particularly in the central nervous system, in NSCLC patients. The LAURA study shows promising results in improving progression-free survival compared… Continue reading Osimertinib after definitive chemoradiotherapy in unresectable stage III epidermal growth factor receptor-mutated non-small-cell lung cancer: analyses of central nervous system efficacy and distant progression from the phase III LAURA study☆
Prime-boost immunization with inactivated human adenovirus type 55 combined with an adjuvant enhances neutralizing antibody responses in mice
AI SummaryThe article discusses a study on prime-boost immunization in mice using inactivated human adenovirus type 55 (hAd55) and an adjuvant. The research found that this approach enhanced neutralizing antibody responses, which could potentially improve immunity against hAd55 infection. This study could have implications for developing vaccines against hAd55 and other adenoviruses that cause acute… Continue reading Prime-boost immunization with inactivated human adenovirus type 55 combined with an adjuvant enhances neutralizing antibody responses in mice
Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics
AI SummaryThe content discusses the rational design of heterobivalent probes targeting both the Prostate-Specific Membrane Antigen (PSMA) and the neurotensin receptor-1 (NTS1) for prostate cancer theranostics. The development of a hybrid probe, JMV 7489, was reported, showing good affinity towards PSMA and lower affinity towards NTS1. The study highlights the importance of the DOTA macrocycle… Continue reading Rational design of NT-PSMA heterobivalent probes for prostate cancer theranostics
TWiV 1149: Mary Estes, a gutsy virologist
AI SummaryMary Estes, a virologist known for her work on viruses that infect the gastrointestinal tract, such as rotavirus and norovirus, discusses her career and research in a podcast episode hosted by Kathy Spindler and Brianne Barker. Key points include rotavirus-induced diarrhea, minimal infective doses of rotavirus, mRNA release from rotavirus particles, and the development… Continue reading TWiV 1149: Mary Estes, a gutsy virologist
TWiV 1148: Clinical update with Dr. Daniel Griffin
AI SummaryIn this clinical update, Dr. Daniel Griffin discusses various topics related to the COVID-19 pandemic, including new virus strains from farmed fur animals, comparisons between mRNA and pox vectored vaccines, telehealth management of the disease, prophylactic treatments, and the effects of various treatments on outcomes. He also covers statistics on SARS-CoV-2 infections, viral load… Continue reading TWiV 1148: Clinical update with Dr. Daniel Griffin
NIH funds new research to combat emerging viruses
AI SummaryThe Albert Einstein College of Medicine has received funding from the NIH for a five-year project to develop vaccines and antibody-based therapies against emerging viruses. The project aims to build on lessons learned from COVID-19 by creating a base of critical knowledge about groups of similar viruses, allowing for the rapid development of specific… Continue reading NIH funds new research to combat emerging viruses