Background Adoptive transfer of T cell receptor gene-engineered T (TCR-T) cells can induce durable anti-cancer responses. TBI-1301 is a novel gene therapy produced by engineering autologous lymphocytes to express an NY-ESO-1-specific TCR using a retrovirus vector encoding siRNA to silence endogenous TCR. In this study, we characterize long-lived persisting transferred TBI-1301 TCR-T cells following adoptive… Continue reading 361 Early differentiation and memory transcription programs drive long-term persistence of NY-ESO-1 specific TCR-T cells in adoptive cell therapy
Tag: Traumatic Brain Injury
Perceived CTE in Former Professional Football Players
This cross-sectional study gathered data using surveys from former professional players of American-style football to gauge how many perceive that they have chronic traumatic encephalopathy and determine clinically relevant correlates, including suicidality.
Perceived CTE and Suicidality—Is Perception Reality?
Chronic traumatic encephalopathy (CTE) is a unique neurodegenerative tauopathy associated with repetitive head impacts (RHIs). By definition, CTE is a neuropathological diagnosis, and it has been frequently diagnosed in deceased American football players. Traumatic encephalopathy syndrome (TES) represents research diagnostic criteria for the clinical syndrome of CTE neuropathology. Initial TES criteria, published in 2014, were… Continue reading Perceived CTE and Suicidality—Is Perception Reality?
Extending CT Stroke Scan to the Heart Boosts Clot Detection
Extending the simple CT scan administered to all acute stroke patients to include the upper part of the heart increased cardioaortic thrombus detection by almost sixfold. Medscape Medical News
The AACR Industry Roundtable 2024: Detecting and Treating Cancer Early
In Ancient Greek legends, Sybil was a name bestowed upon prophetesses who were thought capable of predicting the future. Today, can artificial intelligence help create a modern-day Sybil capable of predicting future cases of lung cancer? That was just one of the questions raised at the American Association for Cancer Research (AACR) Industry Roundtable 2024,… Continue reading The AACR Industry Roundtable 2024: Detecting and Treating Cancer Early
A New, Easily Identifiable, Sign of Concussion?
Researchers have identified a new potential sign of concussion in athletes, particularly football players, that is easily spotted on the field, signaling the need for immediate evaluation. Medscape Medical News
Neoadjuvant Immunotherapy for Liver Cancer: Shrinking Tumors, Growing Responses
In May 2022, Anibal Torres woke up with severe stomach pain that kept him from eating much over the next several days. He was eventually referred to the hospital for a CT scan that revealed a massive tumor in his liver—a hepatocellular carcinoma. At 11.9 cm, it was too large to be surgically removed. A… Continue reading Neoadjuvant Immunotherapy for Liver Cancer: Shrinking Tumors, Growing Responses
[In Context] Andrea Schneider
Andrea Schneider is an assistant professor at the University of Pennsylvania (Philadelphia, PA, USA). She received her MD and PhD in epidemiology from the Johns Hopkins University (Baltimore, MD, USA), where she also completed her neurology and neurocritical care training. Her research programme is centred on traumatic brain injury (TBI) epidemiology and the prevention of… Continue reading [In Context] Andrea Schneider
Meet the nextGEN: James Dooley
AI SummaryJames Dooley’s journey into leadership was influenced by his childhood experiences and desire to care for others. After a car accident prevented him from pursuing a career as a paramedic or physician, he shifted his focus to research, particularly in neurology. Alongside his co-founder, Adrian Liston, they focused on developing treatments for traumatic brain… Continue reading Meet the nextGEN: James Dooley
[ASAP] Curdlan-Mediated Syngeneic RNAi against NF-κB in Glial Cells Protects Cerebral Vessels in the TBI Mouse Model
BiomacromoleculesDOI: 10.1021/acs.biomac.4c01001