Mild traumatic brain injury leads to reactivation of herpes simplex virus type 1, which may promote neurodegeneration and contribute to Alzheimer’s, new research suggested. Medscape Medical News
Tag: Traumatic Brain Injury
Donepezil Shows Promise in TBI Recovery
Donepezil was associated with improved verbal memory and processing speed compared to placebo in patients with TBI and severe, persistent impairments. Medscape Medical News
Dispelling the Concussion Dogma
The Curbsiders consult a concussion expert to find out how to best promote recovery after head injury. The Curbsiders
Study Supports Pediatric Concussion Management Approach
A new analysis also suggests a need for more research on concussions related to sports with the potential for high-velocity impact or falls from great heights. Medscape Medical News
Family Mental Health May Shape Aggression in CTE
Family history of mental illness is linked to aggression, especially in midlife, in individuals with chronic traumatic encephalopathy, new research suggests. Medscape Medical News
Largest study of CTE in male ice hockey players finds odds increased 34% with each year played
A large study, of 77 deceased male ice hockey players, has found that the odds of having chronic traumatic encephalopathy (CTE) increased by 34% each year played, and 18 of 19 National Hockey League players had CTE. CTE is a neurodegenerative disease caused by repeated traumatic brain injuries and most frequently found in former contact… Continue reading Largest study of CTE in male ice hockey players finds odds increased 34% with each year played
A History of Concussion Linked to Maternal Mental Illness
Women with a history of concussion were 25% more likely to have a serious mental illness in the years after childbirth than those without a history of concussion. Medscape Medical News
1352 Impact of timing of real-world CT imaging on cost-effectiveness of a molecular biomarker for treatment response monitoring of immunotherapy
Background Studies have demonstrated that dynamic molecular biomarkers for treatment response monitoring (TRM) of immune checkpoint inhibitors (ICI) can predict clinical outcomes. However, there is little data on when a molecular biomarker is best integrated into clinical practice based on timing of Computed Tomography (CT) imaging. Here, we characterize real-world (RW) imaging patterns in a… Continue reading 1352 Impact of timing of real-world CT imaging on cost-effectiveness of a molecular biomarker for treatment response monitoring of immunotherapy
1212 Utilization of artificial intelligence support for early lung cancer diagnosis in a lung nodule program: a retrospective cohort study
Background This study evaluates combined Artificial Intelligence (AI)-guided lung nodule identification, risk stratification, and tracking in a lung nodule program at a large academic medical center (AMC) as compared to current practice. The primary objective was to assess the number of clinically relevant lung nodules (8–30mm, and/or recommended for follow-up by radiology) that would be… Continue reading 1212 Utilization of artificial intelligence support for early lung cancer diagnosis in a lung nodule program: a retrospective cohort study
315 Improving pediatric neuroblastoma immunotherapy outcome by using B7-H3 CAR-T cells in combination with low-dose external beam radiation therapy (EBRT): preclinical development in murine models
Background High-risk neuroblastoma accounts for ~10% of childhood cancer deaths. Despite improvements in treatment, the 5-year overall survival remains only ~50%. CAR-T cell therapy has shown remarkable success in hematological tumors, including children with relapsed ALL. However, CAR-T cell therapy has shown limited response in high-risk neuroblastoma or other solid tumors due in part to… Continue reading 315 Improving pediatric neuroblastoma immunotherapy outcome by using B7-H3 CAR-T cells in combination with low-dose external beam radiation therapy (EBRT): preclinical development in murine models