Background Although immune checkpoint blockade (ICB) therapy has shown remarkable benefits in cancers, a subset of patients with cancer exhibits unresponsiveness or develop acquired resistance due to the existence of abundant immunosuppressive cells. Tumor-associated macrophages (TAMs), as the dominant immunosuppressive population, impede the antitumor immune response; however, the underlying mechanisms have not been fully elucidated… Continue reading C1q+ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion
Tag: Transplantation and Transplant Rejection
PPAR{gamma} activation modulates the balance of peritoneal macrophage populations to suppress ovarian tumor growth and tumor-induced immunosuppression
Ovarian adenocarcinoma (OVAD) frequently metastasizes to the peritoneal cavity and manifests by the formation of ascites, which constitutes a tumor-promoting microenvironment . 15(S)-hydroxyeicosatetraenoic acid (HETE), a PPAR ligand, is a critical factor participating in macrophage differentiation and cooperates with CCAAT/enhancer binding protein β (C/EBP&beta)
Immunotherapy after stem cell transplantation effectively combats certain childhood nerve tumors
Scientists at St. Anna Children’s Cancer Research Institute and the Eberhard Karls University of Tübingen have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children. Crucially, stem cells from a parent provide children with a new immune system that responds much better to immunotherapies. These results of an early clinical… Continue reading Immunotherapy after stem cell transplantation effectively combats certain childhood nerve tumors
Childhood cancer: ‘New’ immune system responds better to therapy
Scientists have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children . Crucially, stem cells from a parent provide children with a new immune system that responds much better to
Biomarkers Found for Early Detections of GVHD
Researchers have found a new risk biomarker that can detect the early beginnings of graft-versus-host disease in new study.
Transplantation after CD45-ADC corrects Rag1 immunodeficiency in congenic and haploidentical settings.
A cool path to disease deceleration
In 2020, Kathrin “Kat” Kajderowicz’s father passed away from lung cancer. Kajderowicz was in charge of her father’s health care for as long as she can remember. While he suffered from various cardiovascular issues for several years, it wasn’t until the beginning of the Covid-19 pandemic that he was diagnosed with late-stage metastatic small-cell lung… Continue reading A cool path to disease deceleration
Chronic immune-related adverse events in patients with cancer receiving immune checkpoint inhibitors: a systematic review
Immune-related adverse events (irAEs) are toxicities resulting from use of immune checkpoint inhibitors (ICIs) These side effects persist in some patients despite withholding therapy and using immunosuppressive and immune-modulating agents . The most common ICIs delivered were pembrolizumab (24%) and nivolumabs (37%) Most patients (75%) had metastatic disease and the primary cancer site was melanoma… Continue reading Chronic immune-related adverse events in patients with cancer receiving immune checkpoint inhibitors: a systematic review
Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board
Ewing sarcoma is a malignant tumor of bone and soft tissue that most often occurs in adolescents and young adults . Despite an international coordinated approach, several nuances, discrepancies, and debates remain in defining the standard of care for treating ES . This report is focused on select topics that apply to the management of… Continue reading Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board
Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board
Ewing sarcoma is a malignant tumor of bone and soft tissue that most often occurs in adolescents and young adults . Despite an international coordinated approach, several nuances, discrepancies, and debates remain in defining the standard of care for treating ES . This report is focused on select topics that apply to the management of… Continue reading Consensus recommendations in the management of Ewing sarcoma from the National Ewing Sarcoma Tumor Board