Tag: Transplantation and Transplant Rejection

Haematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe: an EBMT Inborn Errors Working Party study

AI SummaryThis study, conducted by the EBMT Inborn Errors Working Party, focused on the use of haematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe. The research aimed to examine the outcomes and efficacy of this treatment approach for individuals with this genetic condition. By analyzing data from different transplant centers, the study provided insights… Continue reading Haematopoietic stem cell transplantation for CTLA-4 insufficiency across Europe: an EBMT Inborn Errors Working Party study

T cells manipulate the memory of innate immune cells

AI SummaryThis article discusses research findings that reveal T cells from the adaptive immune system can influence the memory of innate immune cells, contrary to previous beliefs that these memories operated independently. The study highlights potential implications for disease treatment, such as utilizing this interaction to reduce the need for immunosuppressive drugs post-organ transplantation in… Continue reading T cells manipulate the memory of innate immune cells

Microglia’s heroic battle against neurodegeneration

AI SummaryThis article discusses research published in Neuron that shows how the absence of homeostatic microglia can lead to severe neuropathologies, such as axonal spheroids, calcifications, myelination abnormalities, and gliosis. These conditions are associated with leukoencephalopathy and age-related neurodegeneration. However, the transplantation of healthy microglia has been shown to reverse these conditions, providing new opportunities… Continue reading Microglia’s heroic battle against neurodegeneration

Assessing the utility of the PC‐PTSD‐5 as a screening tool among a cancer survivor sample

AI SummaryThis study assessed the utility of the PC-PTSD-5 as a screening tool among cancer survivors who underwent hematopoietic stem cell transplantation (HCT). The study found that the PC-PTSD-5 exhibited strong internal consistency and a cut score of 4 demonstrated the highest efficiency for detecting probable PTSD. Item 4 of the PC-PTSD-5 (numbing) was particularly… Continue reading Assessing the utility of the PC‐PTSD‐5 as a screening tool among a cancer survivor sample

Assessing the utility of the PC‐PTSD‐5 as a screening tool among a cancer survivor sample

AI SummaryThis study aimed to evaluate the usefulness of the Primary Care PTSD Screen for DSM-5 (PC-PTSD-5) as a screening tool for posttraumatic stress disorder (PTSD) symptoms in cancer survivors who underwent hematopoietic stem cell transplantation (HCT). The research found that the PC-PTSD-5 demonstrated strong internal consistency and was significantly associated with the longer PTSD… Continue reading Assessing the utility of the PC‐PTSD‐5 as a screening tool among a cancer survivor sample

Delineation of features, responses, outcomes, and prognostic factors in pediatric PDGFRB‐positive acute lymphoblastic leukemia patients: A retrospective multicenter study

AI SummaryThis study focused on pediatric patients with PDGFRB-positive acute lymphoblastic leukemia (ALL) and identified high-risk features associated with this rare subclass of ALL. The research showed that chemotherapy in combination with tyrosine-kinase inhibitors improved the complete remission rate, leading to lower levels of measurable residual disease (MRD), potentially offering better survival outcomes for these… Continue reading Delineation of features, responses, outcomes, and prognostic factors in pediatric PDGFRB‐positive acute lymphoblastic leukemia patients: A retrospective multicenter study

Delineation of features, responses, outcomes, and prognostic factors in pediatric PDGFRB‐positive acute lymphoblastic leukemia patients: A retrospective multicenter study

AI SummaryThis study focused on pediatric patients with PDGFRB-positive acute lymphoblastic leukemia (ALL) and identified high-risk features such as older age, high white blood cell count, and increased risk of relapse. They found that treatment with chemotherapy plus tyrosine-kinase inhibitors improved the complete remission rate and lower MRD levels, with MRD ≥0.01% being a powerful… Continue reading Delineation of features, responses, outcomes, and prognostic factors in pediatric PDGFRB‐positive acute lymphoblastic leukemia patients: A retrospective multicenter study

Pre-surgical antibody treatment might prevent heart transplant rejection

AI SummaryThis article suggests that pre-surgical antibody treatment could potentially prevent rejection of heart transplants. Unlike current immunosuppressive agents, specific antibodies could block rejection-related inflammation while preserving anti-microbial immunity, reducing the risk of infections in patients. This approach could offer a more targeted and potentially safer option for preventing rejection in heart transplant recipients.Anti-rejection regimens… Continue reading Pre-surgical antibody treatment might prevent heart transplant rejection