Background Phenotypic heterogeneity of melanoma cells contributes to drug tolerance, increased metastasis, and immune evasion in patients with progressive disease. Diverse mechanisms have been individually reported to shape extensive intra-tumor and inter-tumor phenotypic heterogeneity, such as IFN signaling and proliferative to invasive transition, but how their crosstalk impacts tumor progression remains largely elusive. Methods Here,… Continue reading Dynamical modeling of proliferative-invasive plasticity and IFN{gamma} signaling in melanoma reveals mechanisms of PD-L1 expression heterogeneity
Tag: Systems Biochemistry
3 Questions: Sara Prescott on the brain-body connection
AI SummarySara Prescott, a faculty member in the Department of Biology at MIT, is researching the interoceptive nervous system and its role in detecting and responding to stimuli in the body. Her focus is on the mammalian airway and how neural pathways affect respiratory function and overall health. The goal of her research is to… Continue reading 3 Questions: Sara Prescott on the brain-body connection
New technologies reveal cross-cutting breakdowns in Alzheimer’s disease
After decades of fundamental scientific and drug discovery research, Alzheimer’s disease has remained inscrutable and incurable, with a bare minimum of therapeutic progress. But in a new review article in Nature Neuroscience, MIT scientists write that by employing the new research capability of single-cell profiling, the field has rapidly achieved long-sought insights with strong potential for both… Continue reading New technologies reveal cross-cutting breakdowns in Alzheimer’s disease