Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen.
Tag: Systems Biochemistry
Epigenetic inhibitors show promise in malaria treatment
Epigenetic inhibitors as a promising new antimalarial intervention strategy? A new study identifies an inhibitor of gene regulation that specifically kills the malaria pathogen. A multinational research team led by Professor Markus Meiβner (LMU Munich) and Professor Gernot Längst (University of Regensburg) has gained important insights into the gene regulation of Plasmodium falciparum, the main… Continue reading Epigenetic inhibitors show promise in malaria treatment
H3K27 Trimethylation-Mediated Downregulation of miR-216a-3p in Sensory Neurons Regulates Neuropathic Pain Behaviors via Targeting STIM1
Although the therapeutic potential of microRNA-mediated gene regulation has been investigated, its precise functional regulatory mechanism in neuropathic pain remains incompletely understood. In this study, we elucidate that miR-216a-3p serves as a critical noncoding RNA involved in the modulation of trigeminal-mediated neuropathic pain. By conducting RNA-seq and qPCR analysis, we observed a notable decrease of… Continue reading H3K27 Trimethylation-Mediated Downregulation of miR-216a-3p in Sensory Neurons Regulates Neuropathic Pain Behaviors via Targeting STIM1
Exploring the metabolic potential of Aeromonas to utilise the carbohydrate polymer chitin
Members of the Aeromonas genus are commonly found in natural aquatic ecosystems. However, they are also frequently present in non-chlorinated drinking water distribution systems. High densities of these bacteria indicate favorable conditions for microbial regrowth, which is considered undesirable. Studies have indicated that the presence of Aeromonas is associated with loose deposits and the presence… Continue reading Exploring the metabolic potential of Aeromonas to utilise the carbohydrate polymer chitin
Evaluation of ALKBH2 and ALKBH3 gene regulation in patients with adult T-cell leukemia/lymphoma
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus that causes malignant adult T-cell leukemia/lymphoma (ATL). Patients infected with HTLV-1 are considered HTLV-1 carriers, and a small proportio… Continue reading on BioMed Central
[ASAP] A Biomolecular Circuit for Automatic Gene Regulation in Mammalian Cells with CRISPR Technology
1361 Revolutionizing epigenomic analysis in cancer: high-resolution spatial CUT&Tag and spatial ATAC-seq mapping at the single-nucleus level
Background Advances in spatial transcriptomics and proteomics have enabled increasingly complex investigations into gene expression across various cellular subtypes and tissues.1–3 However, these methods do not explore the epigenome, which regulates gene expression in a cell-specific manner and plays a critical role in human diseases including cancer. A nuanced understanding of epigenetic dysregulation of chromatin… Continue reading 1361 Revolutionizing epigenomic analysis in cancer: high-resolution spatial CUT&Tag and spatial ATAC-seq mapping at the single-nucleus level
324 Network-guided approach to engineering TF perturbations that synergize to counter the pathways of CAR-T cell dysfunction
Background CAR-T cell efficacy in solid tumors is dampened by T-cell dysfunction, especially exhaustion, which is driven by chronic exposure to tumor antigens and the immunosuppressive, nutrient-limited tumor microenvironment. Transcription factor (TF) overexpression or knockout are promising approaches to enhance CAR-T cell durability. However, given that a single genetic modulation is unlikely to sufficiently counter… Continue reading 324 Network-guided approach to engineering TF perturbations that synergize to counter the pathways of CAR-T cell dysfunction
181 Transcriptomic and proteomic spatial profiling of pediatric and adult diffuse midline glioma H3 K27-altered, reveals region specific differences and limited overlap between mRNA and protein
Background Diffuse midline glioma, H3 K27-altered (DMG-Alt) are highly aggressive malignancies of the central nervous system that primarily affect the pediatric population. It is classified as a World Health Organization grade 4 neoplasm with no curative treatments. Large scale spatial transcriptomic studies have implicated that tumor microenvironmental landscape plays an important role in determining the… Continue reading 181 Transcriptomic and proteomic spatial profiling of pediatric and adult diffuse midline glioma H3 K27-altered, reveals region specific differences and limited overlap between mRNA and protein
Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus
Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by -secretase resulting… Continue reading Neuregulin1 Nuclear Signaling Influences Adult Neurogenesis and Regulates a Schizophrenia Susceptibility Gene Network within the Mouse Dentate Gyrus