AI SummaryThis article discusses the development of a multi-signal processing guide RNA by researchers at POSTECH, which can logically regulate gene expression in response to various signals. By combining the CRISPR/Cas system with biocomputing technology, the team was able to achieve precise control of networks of genes to respond to multiple signals, opening up new… Continue reading Multi-signal processing guide RNAs: A new frontier in gene regulation
Tag: Systems Biochemistry
Editors’ Picks, May 2024: Machine Learning in Cancer Research, the Cost of Smoking, and More
AI SummaryThe content provided highlights the Editors’ Picks for May 2024 in various cancer research journals. Some key points summarized include the use of machine learning in cancer research to predict treatment responses, the financial benefits of smoking cessation, the mechanisms of treatment resistance in blood cancer, the efficacy of certain inhibitors in targeting RAS… Continue reading Editors’ Picks, May 2024: Machine Learning in Cancer Research, the Cost of Smoking, and More
An epigenome editing toolkit to dissect the mechanisms of gene regulation
AI SummaryThe article discusses a recent study that has developed an epigenome editing toolkit that allows for precise programming of chromatin modifications at specific positions in the genome. This technology will help researchers understand the causal role of these modifications in transcription regulation and investigate their impact on various biological processes. Additionally, the toolkit may… Continue reading An epigenome editing toolkit to dissect the mechanisms of gene regulation
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification
Multilayered gene regulation orchestrates cell-type-specific cytokine expression. Liu et al. examine the impact of chromatin loop formation on the expression of IFN-γ and IL-22, which are cytokine loci closely located in the genome, and identify an inducible topologically associating domain required for proper IFN-γ production in Th1 cells. Deleting a CTCF-binding site within this domain leads to lineage-specific cytokine dysregulation and increased susceptibility to pathogens.
Enhancer-gene mapping with SCENT method offers insights into disease mechanisms
AI SummaryThe article discusses the development of a statistical method called SCENT (single-cell enhancer target gene mapping) that allows for the mapping of enhancer-gene interactions in various cell types to identify potential causal loci for common and rare diseases. The researchers applied this method to various human tissues and found important insights for immune diseases… Continue reading Enhancer-gene mapping with SCENT method offers insights into disease mechanisms
Contribution of Hfq to gene regulation and virulence in Histophilus somni
Infection and Immunity, Ahead of Print.
A left-handed RNA quadruplex directs gene silencing
Deciphering protein interaction network dynamics with a machine learning-based framework
AI SummaryThe content describes the development of Tapioca, a machine learning-based framework, that accurately predicts protein-protein interaction network dynamics. The framework was used to study host regulation during the reactivation of an oncogenic virus from latency. Through an interactome homology analysis method, a proviral host factor with broad relevance for herpesviruses was identified. This research… Continue reading Deciphering protein interaction network dynamics with a machine learning-based framework
Breakthrough technique unveils secrets of “backtracking” in gene regulation
AI SummarySummary: A new technique has been developed that can determine the frequency and location of a molecular event called “backtracking” in the genome of any species. This event is believed to be a form of gene regulation that influences many human genes involved in basic life processes. The technique was developed by researchers at… Continue reading Breakthrough technique unveils secrets of “backtracking” in gene regulation
Study throws our understanding of gene regulation for a loop
AI SummaryScientists are studying how loop structures in genetic material can repress or silence gene activity, which could impact human health.To function properly, the genetic material is highly organized into loop structures that often bring together widely separated sections of the genome critical to the regulation of gene activity. Scientists now address how these loops… Continue reading Study throws our understanding of gene regulation for a loop