Tag: Stroke

The pathobiology of neurovascular aging

As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.

Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models

Mesenchymal stromal cell (MSC) therapy has regenerative potentials to treat various pathological conditions including neurological diseases. MSCs isolated from various organs can differentiate into specific cell types to repair organ damages. However, their paracrine mechanisms are predicted to predominantly mediate their immunomodulatory, proangiogenic, and regenerative properties. While preclinical studies highlight the significant potential of MSC… Continue reading Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models

Immediate or Delayed Statin in Acute Atherosclerotic Ischemia

To the Editor The recently published data from the Intensive Statin and Antiplatelet Therapy for High-Risk Intracranial or Extracranial Atherosclerosis (INSPIRES) trial did not confirm a benefit in favor of early (within 72 hours) intensive statin vs 3-day delayed-intensive statin in terms of stroke reduction within 90 days in Chinese patients with acute mild ischemic… Continue reading Immediate or Delayed Statin in Acute Atherosclerotic Ischemia

Immediate or Delayed Statin in Acute Atherosclerotic Ischemia—Reply

In Reply With respect to the results of the Intensive Statin and Antiplatelet Therapy for High-Risk Intracranial or Extracranial Atherosclerosis (INSPIRES) study, we did not deny the efficacy of initiating intensive statin therapy for atherosclerotic stroke early after onset; rather, we suggested that it may be potentially associated with short-term functional improvement. Similar to the… Continue reading Immediate or Delayed Statin in Acute Atherosclerotic Ischemia—Reply