PLA2G2E from peri-infarct-surviving neurons metabolizes phosphatidylserine to DGLA and 15-HETrE, which triggers functional recovery after ischemic stroke. These reparative lipid mediators induce PADI4 in peri-infarct-surviving neurons to initiate neural repair-associated gene expression through histone citrullination, demonstrating brain-autonomous extensive repair capabilities through lipid metabolism.
Tag: Stroke
[Articles] The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial
AI SummaryNo differences in the incidence of vascular events were found between patients with ischaemic stroke in the intervention and control groups, despite positive effects on cardiovascular risk factors. Additional evaluation is needed to assess longer-term effects and potential benefits on stroke-related sequelae and quality of life.No differences were identified between patients with ischaemic stroke… Continue reading [Articles] The structured ambulatory post-stroke care program for outpatient aftercare in patients with ischaemic stroke in Germany (SANO): an open-label, cluster-randomised controlled trial
2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
AI SummaryIntermittent fasting can delay cognitive decline and improve conditions like stroke and Alzheimer’s. However, the exact impact of glucose restriction, a part of intermittent fasting, is not fully understood. Researchers used 2-deoxyglucose to investigate how low glucose stimulates brain plasticity and treats stroke and Alzheimer’s.Intermittent fasting (IF) is a nutritional paradigm that forestalls cognitive… Continue reading 2-Deoxyglucose drives plasticity via an adaptive ER stress-ATF4 pathway and elicits stroke recovery and Alzheimer’s resilience
Unraveling connections between the brain and gut
AI SummaryMIT engineers have developed a new technology that allows them to control neural circuits connecting the gut and the brain in mice using fibers embedded with various sensors and light sources. Through their experiments, they were able to manipulate the gut cells to induce feelings of fullness or reward-seeking behavior in the mice, indicating… Continue reading Unraveling connections between the brain and gut
How touch dampens the brain’s response to painful stimuli
AI SummaryResearchers at MIT’s McGovern Institute for Brain Research have observed how touch can alleviate pain in mice, offering a deeper understanding of the relationship between pain and touch and potential insights into chronic pain in humans. The researchers found that whisker movement, which activates touch receptors in mice’s faces, altered their responses to painful… Continue reading How touch dampens the brain’s response to painful stimuli