Ischemic stroke (IS) is a common cerebrovascular disease. Although the formation of atherosclerosis, which is closely related to oxidative stress (OS), is associated with stroke-related deaths. However, the ro…
Tag: Stroke
Dementia Risk Higher for Stroke Survivors
Dementia risk is nearly 80% higher in stroke survivors than in those without stroke, with risk declining within 1 year but remaining elevated for up to 20 years, data show. Medscape Medical News
[ASAP] Correction to “pH/Temperature Dual-Responsive Protein–Polymer Conjugates for Potential Therapeutic Hypothermia in Ischemic Stroke”
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01966
The pathobiology of neurovascular aging
As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral blood flow but also impairs protein clearance, immune function, and neurotrophic homeostasis, thereby increasing the risk of stroke, vascular dementia, and Alzheimer’s disease.
Protective effect of silencing lncRNA HCP5 against brain injury after intracerebral hemorrhage by targeting miR-195-5p
Intracerebral hemorrhage (ICH) is a common subtype of stroke, characterized by a high mortality rate and a tendency to cause neurological damage. This study aims to investigate the role and mechanisms of lncRN…
Prourokinase Rivals Alteplase in Acute Stroke Treatment
Recombinant human prourokinase is noninferior to alteplase and associated with decreased bleeding risks among patients with acute ischemic stroke, a new trial showed. Medscape Medical News
Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models
Mesenchymal stromal cell (MSC) therapy has regenerative potentials to treat various pathological conditions including neurological diseases. MSCs isolated from various organs can differentiate into specific cell types to repair organ damages. However, their paracrine mechanisms are predicted to predominantly mediate their immunomodulatory, proangiogenic, and regenerative properties. While preclinical studies highlight the significant potential of MSC… Continue reading Human iPSC-Derived MSCs Induce Neurotrophic Effects and Improve Metabolic Activity in Acute Neuronal Injury Models
Vertebral Web and Embolic Stroke
This case report describes a female individual in her 30s with headache and vertigo; examination revealed acute embolic infarcts and a lesion on the vertebral artery.
Immediate or Delayed Statin in Acute Atherosclerotic Ischemia
To the Editor The recently published data from the Intensive Statin and Antiplatelet Therapy for High-Risk Intracranial or Extracranial Atherosclerosis (INSPIRES) trial did not confirm a benefit in favor of early (within 72 hours) intensive statin vs 3-day delayed-intensive statin in terms of stroke reduction within 90 days in Chinese patients with acute mild ischemic… Continue reading Immediate or Delayed Statin in Acute Atherosclerotic Ischemia
Immediate or Delayed Statin in Acute Atherosclerotic Ischemia—Reply
In Reply With respect to the results of the Intensive Statin and Antiplatelet Therapy for High-Risk Intracranial or Extracranial Atherosclerosis (INSPIRES) study, we did not deny the efficacy of initiating intensive statin therapy for atherosclerotic stroke early after onset; rather, we suggested that it may be potentially associated with short-term functional improvement. Similar to the… Continue reading Immediate or Delayed Statin in Acute Atherosclerotic Ischemia—Reply