Despite improvements in the treatment of primary uveal melanoma, patients with metastatic disease continue to exhibit poor survival rates . Use of immune checkpoint inhibitors, such as anti-CTLA-4 and anti–PD-1 therapies, were associated with improved survival outcomes . Development of extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold… Continue reading Determinants of overall survival in patients with metastatic uveal melanoma
Tag: Skin Cancer
The highs and lows of serous ovarian cancer
Abstract Low-grade serous ovarian cancer was initially described as a distinct type of rare epithelial ovarian cancer 20 years ago; however, only recently have physicians begun to leverage the understanding of the clinical behavior and molecular profile of this disease for treatment. The use of routine next-generation sequencing has allowed a deeper understanding of the… Continue reading The highs and lows of serous ovarian cancer
The highs and lows of serous ovarian cancer
Low-grade serous ovarian cancer was initially described as a distinct type of rare epithelial cancer 20 years ago . The use of routine next-generation sequencing has allowed a deeper understanding of the molecular drivers of this disease . Endocrine therapy can provide prolonged disease stability with generally mild toxicity, as well as promising response rates… Continue reading The highs and lows of serous ovarian cancer
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
In this study, Zhao et al. report that the PD-L1/PD-1 axis in hippocampal excitatory neurons regulates neuronal excitability, synaptic plasticity, and learning/memory. Blockade of PD-L1 or PD-1 is a new strategy to improve learning and memory in health and disease.