Tag: Skin Cancer

Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia

Only limited efficacy of chimeric antigen receptor T (CAR-T) cell therapy is observed in acute myeloid leukaemia (AML) patients . CD123 and CLL-1 were highly expressed on AML cells . The proportions of T cell subsets and NK cells involved in anti-tumour processes in patients significantly decreased when compared with healthy donors . A possible… Continue reading Valproic acid increases CAR T cell cytotoxicity against acute myeloid leukemia

From the Bench: Creative Approaches in Cancer Research

Improved patient outcomes come from new treatments. New treatments stem from successful clinical trials. Clinical trials build on discoveries made in the lab. And laboratory discoveries? Those rely on a vast array of assays and specialized technologies, combined with the ingenuity of bench scientists who devise, master, and apply these tools in creative ways to… Continue reading From the Bench: Creative Approaches in Cancer Research

Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma

Copy number variants (CNVs) were identified and their relation to disease-free survival (DFS) was studied and validated in an independent cohort of 101 ASCC patients from the Multidisciplinary Spanish Digestive Cancer Group . Mitochondria and mitochondrial cell-cycle proteins were overexpressed in patients with CYP2D6 CNV . This study may be useful to suggest new treatment strategies… Continue reading Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma

Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma

Abstract Background Anal squamous cell carcinoma (ASCC) is an infrequent tumor whose treatment has not changed since the 1970s. The aim of this study is the identification of biomarkers allowing personalized treatments and improvement of therapeutic outcomes. Methods Forty-six paraffin tumor samples from ASCC patients were analyzed by whole-exome sequencing. Copy number variants (CNVs) were… Continue reading Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma

Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma

Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .

Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma

Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .

A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma

Abstract Background Patients with locally advanced head and neck squamous cell cancer (HNSCC) are treated with surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates are high. Immune checkpoint blockade improves survival in patients with recurrent/metastatic HNSCC; however, the role of chemo-immunotherapy in the curative setting is not established. Methods This phase… Continue reading A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma

A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma

Abstract Background Patients with locally advanced head and neck squamous cell cancer (HNSCC) are treated with surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates are high. Immune checkpoint blockade improves survival in patients with recurrent/metastatic HNSCC; however, the role of chemo-immunotherapy in the curative setting is not established. Methods This phase… Continue reading A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma

Determinants of overall survival in patients with metastatic uveal melanoma

Despite improvements in the treatment of primary uveal melanoma, patients with metastatic disease continue to exhibit poor survival rates . Use of immune checkpoint inhibitors, such as anti-CTLA-4 and anti–PD-1 therapies, were associated with improved survival outcomes . Development of extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold… Continue reading Determinants of overall survival in patients with metastatic uveal melanoma