AI SummaryThis article discusses the use of combinatorial innate immunotherapy to overcome resistance within the Ewing sarcoma microenvironment. The study shows that a chimeric antigen receptor (CAR) NK cell targeting MCAM, combined with NKTR-255 (IL-15 agonist) and Magrolimab (CD47 blockade), significantly enhances NK cell cytotoxicity and macrophage phagocytic activity against ES cells. Results from in… Continue reading Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
Tag: Skin Cancer
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling
AI SummaryThis study investigates the role of S100A9 and HMGB1, acting through TLR4 signaling, in the immunosuppression mediated by myeloid-derived suppressor cells (MDSC) in melanoma. The researchers found that exposure to S100A9 and HMGB1 converted monocytes into MDSC through TLR4 signaling. Additionally, elevated plasma levels of S100A8/9 correlated with shorter progression-free survival in melanoma patients.… Continue reading S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
AI SummaryThe research study focuses on the use of anti-IL-10 and anti-PD-1 treatment in controlling SIV viral rebound following analytical treatment interruption in rhesus macaques. The results show that a combination of these treatments led to durable control of viral rebound in most subjects. Key findings included the induction of inflammatory cytokines, proliferation of effector… Continue reading Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Contributions to Colorectal Cancer Disparities
AI SummaryThis article discusses the disparities in colorectal cancer (CRC) outcomes among different racial and ethnic populations in the US, particularly affecting Black and Native American individuals. The study examined data from over 47,000 patients with CRC from a single institution to quantify contributions to these disparities. It found that Black patients with CRC had… Continue reading Contributions to Colorectal Cancer Disparities
Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration
AI SummaryThis research focuses on the role of endosialin-positive cancer-associated fibroblasts (CAFs) in promoting hepatocellular carcinoma (HCC) progression by suppressing CD8+ T cell infiltration. The study found that endosialin knockout led to inhibited tumor growth and increased CD8+ T cell infiltration in mouse models and cell cultures. Endosialin was shown to inhibit the expression and… Continue reading Endosialin-positive CAFs promote hepatocellular carcinoma progression by suppressing CD8+ T cell infiltration
MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers
AI SummaryThis article discusses the use of MHC class I and II-deficient humanized mice as tools to study the long-term efficacy of immune checkpoint inhibitors and T-cell engagers in cancer immunotherapy. The study explores different strategies to overcome xenograft-versus-host disease (xGVHD) in immunodeficient mice engrafted with human PBMCs and co-engrafted with tumor cells. The results… Continue reading MHC class I and II-deficient humanized mice are suitable tools to test the long-term antitumor efficacy of immune checkpoint inhibitors and T-cell engagers
Age-related fibroblast changes in males drive aggressive melanoma
AI SummaryAge-related changes in fibroblasts, which produce the skin’s structure, contribute to the development of aggressive melanoma in males. This research suggests that age and sex-related changes interact to create disparities in melanoma outcomes between men and women. Fibroblasts play a crucial role in this process by promoting the spread of melanoma tumor cells. Age-related… Continue reading Age-related fibroblast changes in males drive aggressive melanoma
Age-related changes in male fibroblasts increase treatment-resistant melanoma
AI SummarySummary: Research shows that age-related changes in male fibroblasts can lead to the development of aggressive and treatment-resistant melanoma. This highlights the importance of understanding how the aging process affects different cell types in the skin and its implications for melanoma treatment.Age-related changes in the fibroblasts, cells that create the skin’s structure, contribute to… Continue reading Age-related changes in male fibroblasts increase treatment-resistant melanoma
Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy
AI SummaryThis study focused on the use of IL-33 targeting to enhance the antitumor response to anti-PD-L1 immunotherapy by reprogramming the tumor microenvironment. The research demonstrated that blocking IL-33 using a fusion protein in combination with anti-PD-L1 treatment increased T cell responses, inhibited tumor progression, and provided long-term protective immunity. Targeting both IL-33 and PD-L1… Continue reading Targeting IL-33 reprograms the tumor microenvironment and potentiates antitumor response to anti-PD-L1 immunotherapy
NKG2C/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastoma
AI SummaryThis study examines the expression of NKG2C/KLRC2 in glioblastoma (GBM) and its potential as a modulator of the tumor microenvironment. Neoplastic KLRC2 expression was associated with reduced myeloid-derived suppressor cells and increased tumor-resident lymphocytes. NKG2Chigh expression correlated with enhanced antitumor activity after treatment with PD-1 monoclonal antibody in both mouse models and GBM patients,… Continue reading NKG2C/KLRC2 tumor cell expression enhances immunotherapeutic efficacy against glioblastoma