Abstract Background Anal squamous cell carcinoma (ASCC) is an infrequent tumor whose treatment has not changed since the 1970s. The aim of this study is the identification of biomarkers allowing personalized treatments and improvement of therapeutic outcomes. Methods Forty-six paraffin tumor samples from ASCC patients were analyzed by whole-exome sequencing. Copy number variants (CNVs) were… Continue reading Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma
Tag: Skin Cancer
Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma
Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .
Cancer‐associated fibroblasts contribute to the immunosuppressive landscape and influence the efficacy of the combination therapy of PD‐1 inhibitors and antiangiogenic agents in hepatocellular carcinoma
Cancer-associated fibroblasts (CAFs) play a key role in HCC TME remodeling . The level of abundance of CAFs may significantly affect the prognosis and outcome in patients . Patients in the CAF high cluster had a higher levels of inflammatory cell infiltration and a more significant immunosuppressive microenvironment .
A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
Abstract Background Patients with locally advanced head and neck squamous cell cancer (HNSCC) are treated with surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates are high. Immune checkpoint blockade improves survival in patients with recurrent/metastatic HNSCC; however, the role of chemo-immunotherapy in the curative setting is not established. Methods This phase… Continue reading A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
Abstract Background Patients with locally advanced head and neck squamous cell cancer (HNSCC) are treated with surgery followed by adjuvant (chemo) radiotherapy or definitive chemoradiation, but recurrence rates are high. Immune checkpoint blockade improves survival in patients with recurrent/metastatic HNSCC; however, the role of chemo-immunotherapy in the curative setting is not established. Methods This phase… Continue reading A phase 2 study of neoadjuvant chemotherapy plus durvalumab in resectable locally advanced head and neck squamous cell carcinoma
Determinants of overall survival in patients with metastatic uveal melanoma
Despite improvements in the treatment of primary uveal melanoma, patients with metastatic disease continue to exhibit poor survival rates . Use of immune checkpoint inhibitors, such as anti-CTLA-4 and anti–PD-1 therapies, were associated with improved survival outcomes . Development of extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold… Continue reading Determinants of overall survival in patients with metastatic uveal melanoma
Determinants of overall survival in patients with metastatic uveal melanoma
Despite improvements in the treatment of primary uveal melanoma, patients with metastatic disease continue to exhibit poor survival rates . Use of immune checkpoint inhibitors, such as anti-CTLA-4 and anti–PD-1 therapies, were associated with improved survival outcomes . Development of extrahepatic-only metastases, better baseline performance status, and female sex contributed to a more than 2-fold… Continue reading Determinants of overall survival in patients with metastatic uveal melanoma
The highs and lows of serous ovarian cancer
Abstract Low-grade serous ovarian cancer was initially described as a distinct type of rare epithelial ovarian cancer 20 years ago; however, only recently have physicians begun to leverage the understanding of the clinical behavior and molecular profile of this disease for treatment. The use of routine next-generation sequencing has allowed a deeper understanding of the… Continue reading The highs and lows of serous ovarian cancer
The highs and lows of serous ovarian cancer
Low-grade serous ovarian cancer was initially described as a distinct type of rare epithelial cancer 20 years ago . The use of routine next-generation sequencing has allowed a deeper understanding of the molecular drivers of this disease . Endocrine therapy can provide prolonged disease stability with generally mild toxicity, as well as promising response rates… Continue reading The highs and lows of serous ovarian cancer
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
In this study, Zhao et al. report that the PD-L1/PD-1 axis in hippocampal excitatory neurons regulates neuronal excitability, synaptic plasticity, and learning/memory. Blockade of PD-L1 or PD-1 is a new strategy to improve learning and memory in health and disease.