Abstract Background Advanced penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with limited success of immune-checkpoint inhibitors (ICIs). Approximately half of pSCC cases are associated with human papillomavirus (HPV) infection. Methods Evaluation was done retrospectively of the landscape of somatic alterations and ICI-related biomarkers in pSCC by using the Caris Life Sciences… Continue reading Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune‐checkpoint inhibitor‐related biomarkers
Tag: Skin Cancer
Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune‐checkpoint inhibitor‐related biomarkers
Penile squamous cell carcinoma (pSCC) is a rare and aggressive malignancy with limited success of immune-checkpoint inhibitors (ICIs) Half of pScc cases are associated with human papillomavirus (HPV) infection . HPV16/18+ tumors were exclusively found to be the most common mutations . Increased tumor mutational burden could serve as a biomarker for predicting therapeutic response… Continue reading Comprehensive genomic profiling of penile squamous cell carcinoma and the impact of human papillomavirus status on immune‐checkpoint inhibitor‐related biomarkers
Types of Skin Cancer and Their Treatments
There are multiple types of skin cancer and treatments to treat the disease, too, explained an expert.
[ASAP] Aptamers Targeting the PD-1/PD-L1 Axis: A Perspective
A medication used for heart conditions improves the efficacy of current treatments for melanoma in mouse models
The administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma, in mouse models of this disease.
Final Results of Neoadjuvant T-VEC Plus Surgery in Advanced Melanoma
This randomized clinical trial presents the final 5-year follow-up results of neoadjuvant talimogene laherparep
Look Who’s Talking: How Electrical Communication Drives Melanoma
It sounds like something out of Frankenstein, but a new study in the AACR journal Cancer Discovery suggests that changes in electrical signals could spark cancer in certain skin cells. Researchers found that the transfer of a neurotransmitter between two types of skin cells dampened electrical activity in the receiving cell and triggered the growth… Continue reading Look Who’s Talking: How Electrical Communication Drives Melanoma
Safety, tolerability, and clinical activity of selinexor in combination with pembrolizumab in treatment of metastatic non–small cell lung cancer
In lung cancer, overexpression of nuclear export proteins can result in inactivation of critical tumor suppressor proteins and cell-cycle regulators . Selinexor in combination with pembrolizumab demonstrated promising antitumor activity in patients with mNSCLC . The therapy-related toxic effects were consistent with the prior safety data for both drugs .
Safety, tolerability, and clinical activity of selinexor in combination with pembrolizumab in treatment of metastatic non–small cell lung cancer
In lung cancer, overexpression of nuclear export proteins can result in inactivation of critical tumor suppressor proteins and cell-cycle regulators . Selinexor in combination with pembrolizumab demonstrated promising antitumor activity in patients with mNSCLC . The therapy-related toxic effects were consistent with the prior safety data for both drugs .
Immunotherapy May Lead to Chronic Side Effects
Many patients with skin cancer who were treated with immune checkpoint inhibition experienced long-term side effects, although some resolved over time, research showed.