The highs and lows of serous ovarian cancer

Low-grade serous ovarian cancer was initially described as a distinct type of rare epithelial cancer 20 years ago . The use of routine next-generation sequencing has allowed a deeper understanding of the molecular drivers of this disease . Endocrine therapy can provide prolonged disease stability with generally mild toxicity, as well as promising response rates… Continue reading The highs and lows of serous ovarian cancer

PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior

In this study, Zhao et al. report that the PD-L1/PD-1 axis in hippocampal excitatory neurons regulates neuronal excitability, synaptic plasticity, and learning/memory. Blockade of PD-L1 or PD-1 is a new strategy to improve learning and memory in health and disease.