AI SummaryThis study explores the epigenetic regulation of PD-1, a key negative regulator of CD8+ T cell activation highly expressed by exhausted T cells in cancer and chronic viral infection. By deleting an exhaustion-specific PD-1 enhancer, researchers observed optimized T cell function in a mouse model of chronic infection, leading to improved control of viral… Continue reading Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
Tag: Skin Cancer
Long-term metastatic melanoma survival dramatically improves on immunotherapy, study finds
AI SummaryThis study highlights the significant improvement in long-term survival rates for patients with metastatic melanoma treated with immune checkpoint inhibitors. The landmark international trial showed that about half of the patients remained cancer-free for 10 years or more after treatment. This finding demonstrates the promising potential of immunotherapy in significantly improving outcomes for patients… Continue reading Long-term metastatic melanoma survival dramatically improves on immunotherapy, study finds
[ASAP] Development and Evaluation of [68Ga]Ga-Labeled Riboflavin Derivative for RFVT3-Targeted PET Imaging of Melanoma in Mice
AI SummaryThis article focuses on the development and evaluation of a radiolabeled riboflavin derivative for PET imaging of melanoma in mice. The study aims to target RFVT3, a potential biomarker for melanoma, using Gallium-68. The findings could contribute to improving early detection and monitoring of melanoma, potentially leading to better treatment outcomes. Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c00209
Ipilimumab with Nivolumab in molecular-Selected patients with castration-resistant PRostate cancer: primary analysis of the Phase 2 INSPIRE trial
AI SummaryThis study focuses on the use of a combination of immune checkpoint inhibitors, Ipilimumab and Nivolumab, in molecularly-selected patients with castration-resistant prostate cancer. The aim is to investigate the efficacy and safety of this treatment approach in a subset of patients who display a more immunogenic profile. The results of this study could provide… Continue reading Ipilimumab with Nivolumab in molecular-Selected patients with castration-resistant PRostate cancer: primary analysis of the Phase 2 INSPIRE trial
Subcutaneous versus intravenous nivolumab for renal cell carcinoma
The evolving oncology treatment paradigm has created an unmet need for administration options that improve patient experiences and healthcare efficiencies.
Pembrolizumab versus ipilimumab for advanced melanoma: 10-year follow-up of the phase 3 KEYNOTE-006 study
AI SummaryThis study compares pembrolizumab and ipilimumab for advanced melanoma, showing that pembrolizumab significantly improves overall survival compared to ipilimumab. The 10-year follow-up data from the phase 3 KEYNOTE-006 study are presented.Pembrolizumab significantly improved overall survival (OS) versus ipilimumab for unresectable advanced melanoma in KEYNOTE-006 (NCT01866319); 10-year follow-up data are presented.
Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
AI SummaryIn a Phase 1 trial, an experimental mRNA cancer vaccine (mRNA-4359) has shown promise in patients with advanced solid cancers such as lung cancer and melanoma. Nineteen patients received between one and nine doses of the vaccine, which created an immune response against cancer. Adverse events were generally mild, including fatigue, injection site pain,… Continue reading Experimental mRNA cancer vaccine shows potential for advanced stage cancer patients in Phase 1 trial
Tumor-reactive T cell clonotype dynamics underlying clinical response to TIL therapy in melanoma
Adoptive cell therapy (ACT) using in vitro expanded tumor-infiltrating lymphocytes (TILs) can be curative in melanoma but has inconsistent clinical responses. Chiffelle, Barras, et al. track TIL clonotypes in melanoma patients through ACT therapy and provide insight into the profiles and dynamics of tumor-specific clonotypes associated with clinical response and features related to non-responsiveness.
Sex matters in how, when, and where melanomas develop, study finds
AI SummaryThe article discusses a study that analyzes long-term melanoma data to understand the differences in melanoma development between men and women. It reveals important insights into melanoma incidence trends based on sex.A study analyzing long-term melanoma data reveals important insights into melanoma incidence trends in men and women.
Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
AI SummaryThis article discusses the use of combinatorial innate immunotherapy to overcome resistance within the Ewing sarcoma microenvironment. The study shows that a chimeric antigen receptor (CAR) NK cell targeting MCAM, combined with NKTR-255 (IL-15 agonist) and Magrolimab (CD47 blockade), significantly enhances NK cell cytotoxicity and macrophage phagocytic activity against ES cells. Results from in… Continue reading Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy