AI SummaryThis article discusses the use of molecular techniques to add epitope tags to neuromodulatory G-protein-coupled receptors in Drosophila. The study generated constitutive and conditional tagged alleles for several receptors, allowing for the visualization of their cellular and subcellular localization. The study revealed new insights into the localization of receptors in the brain and their… Continue reading Constitutive and Conditional Epitope Tagging of Endogenous G-Protein-Coupled Receptors in Drosophila
Tag: Sensory and Motor Systems
Phase-Dependent Visual and Sensorimotor Integration of Features for Grasp Computations before and after Effector Specification
AI SummaryThe study explores how grasp computations integrate multiple task features during different phases of grasping. Using EEG and dissimilarity analysis, the research findings suggest that the brain forms superadditive integrated representations of grasp features before and after effector specification. These observations highlight the importance of considering nonlinear motor control and the integration of multiple… Continue reading Phase-Dependent Visual and Sensorimotor Integration of Features for Grasp Computations before and after Effector Specification
Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections
AI SummaryThe study examined the precision of cell-type-specific ipsilateral and contralateral cortical projections in transgenic mice of both sexes. It found that while sensory and motor cortical areas had strong topographic outputs to ipsilateral targets, the frontal cortical areas had high degrees of topographic similarity for both ipsilateral and contralateral projections. This suggests that corticostriatal… Continue reading Symmetry in Frontal But Not Motor and Somatosensory Cortical Projections
The Consolidation of Newly Learned Movements Depends upon the Somatosensory Cortex in Humans
AI SummaryIn a study, researchers found that the somatosensory cortex is involved in the retention of newly learned movements in humans, rather than the motor cortex. Through the use of continuous theta-burst stimulation (cTBS), impairments in motor memory were observed when the primary somatosensory cortex was stimulated shortly after learning, compared to stimulation of the… Continue reading The Consolidation of Newly Learned Movements Depends upon the Somatosensory Cortex in Humans
Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant
AI SummaryThis article focuses on characterizing a transgenic mouse model carrying a missense variant in the Grin2b gene associated with intellectual disability and autism spectrum disorder. The study found that neurons from mice carrying this variant showed reduced NMDA receptor currents, faster deactivation of excitatory postsynaptic currents, and decreased sensitivity to a GluN2B-selective antagonist. Behavioral… Continue reading Characterization of Mice Carrying a Neurodevelopmental Disease-Associated GluN2B(L825V) Variant
Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla
AI SummaryThe study focused on the molecular organization of neurons in the ventrolateral medulla (VLM) in mice, a crucial region for visceral and somatic control in the brain. Using single-cell RNA sequencing, the researchers identified 23 subtypes of neurons and five subtypes of astrocytes in the VLM. They found that spinally-projecting neurons were abundant in… Continue reading Molecular Organization of Autonomic, Respiratory, and Spinally-Projecting Neurons in the Mouse Ventrolateral Medulla
Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions
AI SummaryThe article discusses how the neocortex integrates spatial context and sensory information during navigation and how this is affected by dorsal hippocampal lesions. The study used two-photon microscopy in mice to observe neural activity in different cortical regions before and after hippocampal lesions. Results showed that in familiar environments, the hippocampus continues to modulate… Continue reading Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions
Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity
AI SummaryThis article explores the role of the metabotropic glutamate receptor 8 (mGlu8) in modulating excitatory transmission in the dorsal thalamus and sensorimotor activity. The study demonstrates that perturbing grm8 signaling in the thalamocortical circuit leads to increased excitatory drive onto dorsal thalamus relay cells and impairs sensorimotor gating in mice. Additionally, the research shows… Continue reading Thalamocortical mGlu8 Modulates Dorsal Thalamus Excitatory Transmission and Sensorimotor Activity
[Articles] Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
AI SummaryThis article discusses the safety, tolerability, and pharmacokinetics of the antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis (ALS), based on a phase 1 study. The study did not show a reduction in neurofilament levels or benefit on clinical outcomes compared to the placebo group, leading to the discontinuation of BIIB078 clinical… Continue reading [Articles] Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study
[Comment] Targeting C9orf72 in people with ALS
AI SummaryIn people with ALS, targeting C9orf72 could potentially offer a new avenue for treatment. ALS is a devastating disease that leads to paralysis and ultimately death, often due to respiratory failure. Cognitive and behavioral symptoms can also manifest in some individuals. By focusing on C9orf72, researchers aim to address the underlying mechanisms of ALS… Continue reading [Comment] Targeting C9orf72 in people with ALS