Tag: Sensory and Motor Systems

Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson’s Disease and Progressive Supranuclear Palsy

AI SummaryStructural imaging of the locus coeruleus (LC) and behavioral modeling confirm that LC integrity is associated with response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy. This suggests that the noradrenergic system could be a potential target for treating impulsivity in these conditions, and treatment optimization may benefit from stratification based on LC… Continue reading Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson’s Disease and Progressive Supranuclear Palsy

Ariel Furst and Fan Wang receive 2023 National Institutes of Health awards

The National Institutes of Health (NIH) has awarded grants to MIT’s Ariel Furst and Fan Wang, through its High-Risk, High-Reward Research program. The NIH High-Risk, High-Reward Research program awarded 85 new research grants to support exceptionally creative scientists pursuing highly innovative behavioral and biomedical research projects. Ariel Furst was selected as the recipient of the NIH… Continue reading Ariel Furst and Fan Wang receive 2023 National Institutes of Health awards

Inner Retinal Thickness Changes in Prevalent and Incident Parkinson Disease: A Potential Biomarker With Prognostic Value?

AI SummaryThe text discusses the loss of dopaminergic neurons in Parkinson’s disease and different studies that have examined changes in the retina of patients with Parkinson’s disease. The results of these studies have been inconsistent and the implications for clinical practice are unclear.Parkinson disease (PD) neuropathology is characterized by a loss of nigrostriatal dopaminergic neurons.… Continue reading Inner Retinal Thickness Changes in Prevalent and Incident Parkinson Disease: A Potential Biomarker With Prognostic Value?

Connectivity by the Frontal Aslant Tract (FAT) Explains Local Functional Specialization of the Superior and Inferior Frontal Gyri in Humans When Choosing Predictive over Reactive Strategies: A Tractography-Guided TMS Study

AI SummaryThe study investigates how predictive and reactive behaviors are mediated by the frontal aslant tract (FAT) in the brain. The results show that stimulation of specific areas in the superior frontal gyrus (SFG) and inferior frontal gyrus (IFG) can increase either reactive or predictive behavior, and these areas are connected by the FAT. This… Continue reading Connectivity by the Frontal Aslant Tract (FAT) Explains Local Functional Specialization of the Superior and Inferior Frontal Gyri in Humans When Choosing Predictive over Reactive Strategies: A Tractography-Guided TMS Study

Rapid, Activity-Dependent Intrinsic Plasticity in the Developing Zebra Finch Auditory Cortex

AI SummaryNeurons in the zebra finch auditory cortex can rapidly change their firing dynamics in response to a complex acoustic environment and increased expression of the low-threshold potassium channel Kv1.1. This plasticity allows neurons to adapt their firing dynamics and may be important for auditory learning during a crucial period of development. Summary unavailable.The acoustic… Continue reading Rapid, Activity-Dependent Intrinsic Plasticity in the Developing Zebra Finch Auditory Cortex

The Cerebellum as the Central Hub of a Widespread Network in Essential Tremor

Essential tremor (ET) is the most common movement disorder affecting an estimated 0.5 percent of people worldwide and 5 percent of adults older than 65 years.1 While ET is defined as tremor in the upper extremities, many patients also have other neurologic signs and symptoms, including tremor in other body parts, other motor symptoms, mild… Continue reading The Cerebellum as the Central Hub of a Widespread Network in Essential Tremor

Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis

AI SummaryThe study found that while brain abnormalities in essential tremor (ET) are located in various regions, they are connected to a common functional network. The cerebellum was identified as the central hub of this network, which is similar to the therapeutic network for ET. The study suggests that this network could be useful for… Continue reading Mapping Essential Tremor to a Common Brain Network Using Functional Connectivity Analysis

Association of Acute Infarct Topography With Development of Cerebral Palsy and Neurologic Impairment in Neonates With Stroke

Background and Objectives Research investigating neonatal arterial ischemic stroke (NAIS) outcomes have shown that combined cortical and basal ganglia infarction or involvement of the corticospinal tract predict cerebral palsy (CP). The research question was whether voxel-based lesion-symptom mapping (VLSM) on acute MRI can identify brain regions associated with CP and neurodevelopmental impairments in NAIS. Methods… Continue reading Association of Acute Infarct Topography With Development of Cerebral Palsy and Neurologic Impairment in Neonates With Stroke