AI SummaryConnectomics, the study of mapping animal brains, is advancing with the help of powerful electron microscopes and artificial intelligence (AI). The integration of AI allows for a faster and more precise examination of the brain’s intricate network of synapses and neurons. By embedding a GPU into the microscope’s support computer, researchers can run machine-learning… Continue reading Using AI to optimize for rapid neural imaging
Tag: Sensory and Motor Systems
Patient Travel Distance to Neurologist Visits
Background and Objectives The density of neurologists within a given geographic region varies greatly across the United States. We aimed to measure patient travel distance and travel time to neurologist visits, across neurologic conditions and subspecialties. Our secondary goal was to identify factors associated with long-distance travel for neurologic care. Methods We performed a cross-sectional… Continue reading Patient Travel Distance to Neurologist Visits
Attachment Reminders Trigger Widespread Synchrony across Multiple Brains
AI SummaryInfant stimuli generate significant neural and behavioral responses in adults, indicating the importance of primary attachment. This study explores whether attachment reminders also create cross-brain concordance and increase neural uniformity. The results show that attachment cues trigger widespread cross-brain synchrony, particularly in areas related to caregiving and social cues. This suggests that attachment bonds… Continue reading Attachment Reminders Trigger Widespread Synchrony across Multiple Brains
Presynaptic Kainate Receptors onto Somatostatin Interneurons Are Recruited by Activity throughout Development and Contribute to Cortical Sensory Adaptation
AI SummaryExcitatory synapses onto somatostatin interneurons in the barrel cortex are regulated by sensory activity and undergo an activity-dependent presynaptic modulation using GluK2-KARs. Loss of GluK2-KARs and mGluR7 leads to a decrease in sensory adaptation.Somatostatin (SST) interneurons produce delayed inhibition because of the short-term facilitation of their excitatory inputs created by the expression of metabotropic… Continue reading Presynaptic Kainate Receptors onto Somatostatin Interneurons Are Recruited by Activity throughout Development and Contribute to Cortical Sensory Adaptation
Jaw-Opening Dystonia Associated With Spinocerebellar Ataxia Type 48
AI SummaryA 56-year-old woman has experienced a progressive gait imbalance for the past 10 years, along with other movement disorders. She has been diagnosed with an autosomal-dominant spinocerebellar ataxia 48 caused by a mutation in the STUB1 gene. This case represents a unique manifestation of the disease.A 56-year-old woman noticed progressive gait imbalance 10 years… Continue reading Jaw-Opening Dystonia Associated With Spinocerebellar Ataxia Type 48
Clinical Reasoning: A 48-Year-Old Man With Spasticity and Progressive Ataxia
AI SummaryA man with progressive symptoms was diagnosed with a rare late-onset ataxia after extensive testing. The report emphasizes the importance of targeted gene testing to avoid delays in diagnosis.A 48-year-old man was referred to the movement disorders clinic for 10 years of progressive slurred speech, spasticity, limb incoordination, and wide-based gait. Extensive neurologic workup… Continue reading Clinical Reasoning: A 48-Year-Old Man With Spasticity and Progressive Ataxia
Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis
Patients with amyotrophic lateral sclerosis (ALS) demonstrate great heterogeneity in the age at onset (AAO), which is closely related to the course of disease. However, most genetic studies focused on the risk…
Regulation of cortical hyperexcitability in amyotrophic lateral sclerosis: focusing on glial mechanisms
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons, resulting in muscle weakness, atrophy, paralysis, and eventually…
Radial astrocyte synchronization modulates the visual system during behavioral-state transitions
AI SummaryZebrafish larvae change behavior when strongly stimulated, involving an escape response followed by freezing. This is due to glia-neuron interaction, allowing the nervous system to self-regulate.Uribe-Arias et al. show that upon strong sensory stimulation, zebrafish larvae change their behavioral state, characterized by an escape response followed by freezing. This behavioral transition is mediated by the… Continue reading Radial astrocyte synchronization modulates the visual system during behavioral-state transitions
[Editorial] Speeding up research to improve the lives of people with ALS
AI SummaryAdvances in ALS research have increased understanding of the disease, while patient activism aims to raise awareness and funding. European initiatives have been created to accelerate drug development and clinical trials.Advances in research over the past few years have provided a greater understanding of the pathophysiology, genetics, and risk factors for amyotrophic lateral sclerosis… Continue reading [Editorial] Speeding up research to improve the lives of people with ALS