Influenza virus, an RNA virus of the Orthomyxoviridae family, is responsible for widespread seasonal epidemics that result in 3 to 5 million severe illnesses and more than half a million deaths annually. Given the persistent circulation of pandemic influenza variants and increasing resistance to available inhibitors, there is an urgent need for new antiviral drugs… Continue reading Beyond Natural Flavonoids: Exploring Bioisosterism in Design and Synthesis of Influenza Endonuclease Inhibitors
Tag: RNA Viruses
Chicken GSDME, a major pore-forming molecule responsible for RNA virus-induced pyroptosis in chicken
Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication
Cell surface RNA virus nucleocapsid proteins: a viral strategy for immunosuppression?
AI SummaryThis article discusses the role of nucleocapsid protein (N) or nucleoprotein (NP) in RNA viruses and its potential for immunosuppression. N proteins coat the viral genome, protecting it from immune sensors and inducing strong antibody and T cell responses. N proteins are often highly expressed and can be found on the infected cell surface,… Continue reading Cell surface RNA virus nucleocapsid proteins: a viral strategy for immunosuppression?
Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses
1mΨ influences the performance of various positive-stranded RNA virus-based replicons
AI SummaryThis research focuses on the impact of incorporating the modified nucleoside N1-methyl-pseudouridine (1mΨ) into self-amplifying RNAs (saRNAs) used in vaccine platforms based on different positive-stranded RNA viruses. The study found that the effects of 1mΨ varied depending on the specific virus backbone, with impairments in different stages of the replication process observed. While TNCL… Continue reading 1mΨ influences the performance of various positive-stranded RNA virus-based replicons
Oxysterol binding protein (OSBP) contributes to hepatitis E virus replication
Hepatitis E virus (HEV) is a positive-sense, single-stranded RNA virus and causes primarily acute self-limiting infections. The ORF1 of the HEV genome encodes a polyprotein around 190 kDa, which contains sever… Continue reading on BioMed Central
Researchers discover ‘trojan horse’ virus hiding in human parasite
AI SummaryResearchers have discovered a new RNA virus that is potentially worsening the symptoms of toxoplasmosis in humans infected with the parasite Toxoplasma gondii. The virus is believed to be hiding within the parasite and is associated with severe inflammation in infected individuals. This finding could have significant implications for understanding and treating toxoplasmosis.An international… Continue reading Researchers discover ‘trojan horse’ virus hiding in human parasite
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation
TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. Bérouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for TLR7 activation, thus providing insights into immune recognition of exogenous RNAs, with potential therapeutic implications.
The regulation of cGAS-STING signaling by RNA virus-derived components
AI SummarySummary: The content discusses the regulation of cGAS-STING signaling by RNA virus-derived components. The cGAS-STING pathway plays a crucial role in the innate immune response and is associated with a range of human diseases. The article likely delves into how RNA virus components affect this signaling pathway, potentially impacting immune responses and disease outcomes.The… Continue reading The regulation of cGAS-STING signaling by RNA virus-derived components