AI SummaryThis article discusses the role of nucleocapsid protein (N) or nucleoprotein (NP) in RNA viruses and its potential for immunosuppression. N proteins coat the viral genome, protecting it from immune sensors and inducing strong antibody and T cell responses. N proteins are often highly expressed and can be found on the infected cell surface,… Continue reading Cell surface RNA virus nucleocapsid proteins: a viral strategy for immunosuppression?
Tag: RNA Viruses
Zinc-finger CCHC-type containing protein 8 promotes RNA virus replication by suppressing the type-I interferon responses
1mΨ influences the performance of various positive-stranded RNA virus-based replicons
AI SummaryThis research focuses on the impact of incorporating the modified nucleoside N1-methyl-pseudouridine (1mΨ) into self-amplifying RNAs (saRNAs) used in vaccine platforms based on different positive-stranded RNA viruses. The study found that the effects of 1mΨ varied depending on the specific virus backbone, with impairments in different stages of the replication process observed. While TNCL… Continue reading 1mΨ influences the performance of various positive-stranded RNA virus-based replicons
Oxysterol binding protein (OSBP) contributes to hepatitis E virus replication
Hepatitis E virus (HEV) is a positive-sense, single-stranded RNA virus and causes primarily acute self-limiting infections. The ORF1 of the HEV genome encodes a polyprotein around 190 kDa, which contains sever… Continue reading on BioMed Central
Researchers discover ‘trojan horse’ virus hiding in human parasite
AI SummaryResearchers have discovered a new RNA virus that is potentially worsening the symptoms of toxoplasmosis in humans infected with the parasite Toxoplasma gondii. The virus is believed to be hiding within the parasite and is associated with severe inflammation in infected individuals. This finding could have significant implications for understanding and treating toxoplasmosis.An international… Continue reading Researchers discover ‘trojan horse’ virus hiding in human parasite
Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation
TLR7 is critical for recognizing RNA virus infection and initiating antiviral responses. Bérouti et al. demonstrate how RNase T2 and PLD exonucleases generate RNA fragments for TLR7 activation, thus providing insights into immune recognition of exogenous RNAs, with potential therapeutic implications.
The regulation of cGAS-STING signaling by RNA virus-derived components
AI SummarySummary: The content discusses the regulation of cGAS-STING signaling by RNA virus-derived components. The cGAS-STING pathway plays a crucial role in the innate immune response and is associated with a range of human diseases. The article likely delves into how RNA virus components affect this signaling pathway, potentially impacting immune responses and disease outcomes.The… Continue reading The regulation of cGAS-STING signaling by RNA virus-derived components
Viruses that can help ‘dial up’ carbon capture in the sea
AI SummaryIn this article, scientists are exploring the potential of using viruses found in the world’s oceans to aid in carbon capture efforts to combat climate change. They are specifically focusing on identifying viruses that can help trap carbon dioxide in seawater and prevent methane release from thawing Arctic soil. This research could potentially lead… Continue reading Viruses that can help ‘dial up’ carbon capture in the sea
Discovery of a third RNA virus linage in extreme environments Jan 17, 2024
AI SummaryA new RNA virus has been found in a hot spring, indicating that RNA viruses can survive in extreme temperatures. This suggests the possibility of a third kingdom of RNA viruses.A research group has discovered a novel RNA viral genome from microbes inhabiting a high-temperature acidic hot spring. Their study shows that RNA viruses… Continue reading Discovery of a third RNA virus linage in extreme environments Jan 17, 2024
649 Phase 1a open-label, non-randomized, multi-center clinical trial of intratumoral IVX037 in patients with advanced microsatellite stable (MSS) colorectal, gastroesophageal or ovarian cancer
Background Oncolytic viruses have emerged as promising therapeutic agents to selectively infect and destroy cancer cells while synergizing with checkpoint inhibitors to increase efficacy of immunotherapy. IVX037 is a novel bio-selected, receptor targeted, non-genetically modified, naturally occurring oncolytic strain of a human enteric RNA picornavirus. It is a non-enveloped, single-positive-stranded RNA virus with a capsid… Continue reading 649 Phase 1a open-label, non-randomized, multi-center clinical trial of intratumoral IVX037 in patients with advanced microsatellite stable (MSS) colorectal, gastroesophageal or ovarian cancer