Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress

Cerebral amyloid angiopathy (CAA) is a devastating condition common in patients with Alzheimer’s disease but also observed in the general population. Vascular oxidative stress and neurovascular dysfunction hav…

A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan

AI SummaryXu et al. discovered a new immune modulator in Drosophila that connects aging-related factors: neuroinflammation, dysbiosis, oxidative stress, and sleep decline.Xu et al. used Drosophila to identify a novel immune modulator that mediates a brain-gut-brain axis, connecting four aspects of aging: neuroinflammation, dysbiosis, oxidative stress, and sleep decline.