Tag: Redox Biochemistry

304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors

Background Adoptive T cell therapies are widely considered to be the next frontier in cancer immunotherapy treatment but are currently only effective at treating cancers that do not form solid tumors. Tumor-infiltrating lymphocytes (TILs) become ‘exhausted’ in the hostile tumor environment where they lose effector function and express numerous inhibitor receptors, hindering their ability to… Continue reading 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors

199 Quantitative and spatial characteristics of TIL in inflammatory neighborhoods of advanced melanoma tumors

AI SummaryThe text describes a study that explores the role of the tumor immune microenvironment (TIME) in advanced melanoma patients and the association between tumor infiltrating lymphocytes (TIL) and innate inflammation markers. Proteomics approaches were used to analyze the cellular profiles of patient tumors, and significant differences were found in the cellular landscape between high-TIL… Continue reading 199 Quantitative and spatial characteristics of TIL in inflammatory neighborhoods of advanced melanoma tumors

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis

Although gasdermins are known to damage mitochondria during pyroptosis, the mechanism responsible and its importance in executing cell death are not known. Here, Miao et al. show that mitochondrial damage is a “point of no return” that is critical for cell death and inflammation—activated gasdermins bind to mitochondrial cardiolipin to form mitochondrial pores that destroy both mitochondrial membranes, leading to ROS, loss of oxidative phosphorylation, release of cytotoxic mediators, and mitophagy.

897-E STING-activating nanosystem for synergistic immuno-sonodynamic therapy of pancreatic cancer

AI SummaryA new class of oxygen-carrying nanoparticles has been developed to deliver STING agonists and enhance sonodynamic therapy (SDT) for pancreatic cancer. These nanoparticles can penetrate cancer cells, generate reactive oxygen species (ROS), and release drugs triggered by ROS. They accumulate specifically in tumor sites, alleviate tumor hypoxia, and induce a synergistic effect between SDT… Continue reading 897-E STING-activating nanosystem for synergistic immuno-sonodynamic therapy of pancreatic cancer

P37-7 Influence of cytosol calcium ion level on PDT efficacy in nasopharyngeal carcinoma cell line

Nasopharyngeal carcinoma (NPC) is one of the prevalent cancers among the Asian population. Photodynamic therapy (PDT) is a novel treatment approach for NPC that eradicates its biological targets via the generation of reactive oxygen species (ROS) by the combined usage of photosensitizer (PS), molecular oxygen, and light. PDT treatment with high specificity results in an… Continue reading P37-7 Influence of cytosol calcium ion level on PDT efficacy in nasopharyngeal carcinoma cell line

Editors’ Picks: October Highlights From the AACR Journals

As you prepare for trick-or-treating, check out the articles selected by the editors of the 10 AACR journals for the month of October. Highlights include studies on the regulation of electrical activity between melanoma cells and keratinocytes; the role of cancer care providers in HPV vaccine delivery among pediatric, adolescent, and young adult cancer survivors;… Continue reading Editors’ Picks: October Highlights From the AACR Journals

What Are the Functions of Zinc in the Nervous System?

Zinc (Zn, Zn2+) is an essential nutrient that has multiple fundamental functions in the developing and adult nervous system.1-5 Zinc is a structural and regulatory catalyst ion for all major classes of enzymes6; it stabilizes zinc-finger proteins involved in transcriptional regulation and protein maturation7, functions as an intracellular signaling molecule,5 and is released from glutamatergic… Continue reading What Are the Functions of Zinc in the Nervous System?

C-reactive protein impairs immune response of CD8+ T cells via Fc{gamma}RIIb-p38MAPK-ROS axis in multiple myeloma

Background C-reactive protein (CRP) is a prototypical acute phase protein in humans with the function of regulating immune cells. Serum CRP levels are elevated in multiple myeloma (MM), associated with MM cell proliferation and bone destruction. However, its direct effects on T lymphocytes in MM have not been elucidated. Methods Public data sets were used… Continue reading C-reactive protein impairs immune response of CD8+ T cells via Fc{gamma}RIIb-p38MAPK-ROS axis in multiple myeloma