Tag: Redox Biochemistry

Furoxan-Piplartine Hybrids as Effective NO Donors and ROS Inducers in PC3 Cancer Cells: Design, Synthesis, and Biological Evaluations

AI SummaryThis article discusses the creation and evaluation of Furoxan-Piplartine hybrids as potential anti-cancer compounds. These hybrids were found to be more cytotoxic and selective in cancer cells compared to their precursors. Specifically, PC3 cells were most sensitive to certain hybrids, with NO generation and ROS induction observed. The compounds were shown to induce apoptosis… Continue reading Furoxan-Piplartine Hybrids as Effective NO Donors and ROS Inducers in PC3 Cancer Cells: Design, Synthesis, and Biological Evaluations

[ASAP] Examining Hemin and its Derivatives: Induction of Heme-Oxygenase-1 Activity and Oxidative Stress in Breast Cancer Cells through Collaborative Experimental Analysis and Molecular Dynamics Simulations

AI SummaryThis article discusses the examination of Hemin and its derivatives in inducing Heme-Oxygenase-1 activity and oxidative stress in breast cancer cells. The study involves collaborative experimental analysis and molecular dynamics simulations to understand the mechanisms involved. The research aims to provide insights into potential therapeutic targets in breast cancer treatment.

Blockade of glucose-6-phosphate dehydrogenase induces immunogenic cell death and accelerates immunotherapy

AI SummaryThe article discusses the potential of blocking glucose-6-phosphate dehydrogenase (G6PD) to induce immunogenic cell death and enhance the effectiveness of immunotherapy in cancer treatment. Research showed that inhibition of G6PD decreased NADPH levels, increased oxidative stress tolerance, and led to cell death, releasing proteins that promote immune response. In mouse models and patient studies,… Continue reading Blockade of glucose-6-phosphate dehydrogenase induces immunogenic cell death and accelerates immunotherapy

Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in A{beta} Pathology

AI SummaryKey Points: – The study explores the relationship between arachidonic acid (ARA) mobilization and microglial dysfunction in Alzheimer’s Disease (AD) pathology. – Lipidomic analysis of microglia from AppNL-GF mice shows increased free ARA and lysophospholipids (LPLs) and a decreased in ARA-containing phospholipids, suggesting increased ARA release from phospholipids. – Loss of lysophosphatidylcholine acyltransferase 3… Continue reading Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in A{beta} Pathology

Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: in vitro cell-based anticancer studies

AI SummaryThe article discusses the synthesis and testing of new binary heterocyclic molecules containing 1,3,4-thiadiazole-2-yl-imino-thiazolidine-4-one for their anticancer properties. The compounds showed higher cytotoxicity on various cancer cell lines compared to a reference molecule. One compound, 6e, displayed the most potent activity on MCF-7 cell lines, inducing apoptosis, cell cycle arrest, and ROS accumulation. This… Continue reading Synthesis and antiproliferative potency of 1,3,4-thiadiazole and 1,3-thiazolidine-4-one based new binary heterocyclic molecules: in vitro cell-based anticancer studies