Acute lung injury (ALI) is a multifactorial respiratory disease characterized by uncontrolled inflammatory response and has high morbidity and mortality. There is currently a lack of effective drug for ALI treatment. In this study, through the nitric oxide (NO) release inhibition and cytotoxicity screening from in-house compound library, hit compound 6 was discovered. Using 2,4,5-trichloropyrimidine… Continue reading Discovery of a novel pyrimidine derivative for treatment of acute lung injury through reducing oxidative stress and inflammatory response
Tag: Redox Biochemistry
[ASAP] Network-Based Drug Optimization toward the Treatment of Parkinson’s Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation
Yellow dye from the bloodred webcap fungus may be harmful to humans—red dye could be a safe alternative
[ASAP] Hypoxia-Initiated Supramolecular Free Radicals Induce Intracellular Polymerization for Precision Tumor Therapy
[ASAP] Cathode Design Based on Nitrogen Redox and Linear Coordination of Cu Center for All-Solid-State Fluoride-Ion Batteries
Identification of key genes associated with oxidative stress in ischemic stroke via bioinformatics integrated analysis
Ischemic stroke (IS) is a common cerebrovascular disease. Although the formation of atherosclerosis, which is closely related to oxidative stress (OS), is associated with stroke-related deaths. However, the ro…
[ASAP] Macrophage Membrane-Cloaked ROS-Responsive Albumin Nanoplatforms for Targeted Delivery of Curcumin to Alleviate Acute Liver Injury
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.4c00808
How Does Alcohol Consumption Impact Cancer Risk?
Which one do you think is higher each year in the United States: alcohol-related traffic fatalities or alcohol-related cancer deaths? It may surprise you to learn that the answer is alcohol-related cancer deaths with about 20,000 each year, compared with 13,500 traffic fatalities connected to alcohol. Fewer than half of Americans are even aware that… Continue reading How Does Alcohol Consumption Impact Cancer Risk?
Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5-a]pyridine-based chalcones
In continuation of our efforts to develop new anticancer compounds, a new series of imidazo[1,5-a]pyridine-chalcone derivatives was designed, synthesized, characterized, and evaluated for its cytotoxicity against five human cancer cell lines, i.e., breast (MDA-MB-231), colon (RKO), bone (Mg-63), prostate (PC-3), and liver (HepG2) cell lines, as well as a normal cell line (HEK). Among the… Continue reading Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5-a]pyridine-based chalcones
[ASAP] Exploiting the Electrostatic Binding of Ruthenium Hexamine Molecular Redox Nanowires onto DNA/OGCN Biohybrid Electrodes toward the Electrochemical Detection of COVID-19
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01573