AI SummaryThis study focuses on the use of pembrolizumab in combination with adjuvant chemotherapy in patients with newly diagnosed, high-risk endometrial cancer. The research aims to evaluate the potential benefits of this treatment approach in patients without residual macroscopic disease post-surgery. Previous findings show that pembrolizumab plus chemotherapy can be beneficial for advanced endometrial cancer,… Continue reading ENGOT-en11/GOG-3053/KEYNOTE-B21: A Randomised, Double-Blind, Phase 3 Study of Pembrolizumab or Placebo Plus Adjuvant Chemotherapy With or Without Radiotherapy in Patients With Newly Diagnosed, High-Risk Endometrial Cancer
Tag: Radiation Oncology
Accrual to Radiotherapy Trials in the US
AI SummaryThis Viewpoint addresses challenges with patient accrual to radiotherapy cooperative group trials in the US and suggests potential solutions to improve participation rates. The article likely highlights the importance of increasing enrollment in clinical trials to advance research and improve patient outcomes in the field of radiation therapy.This Viewpoint discusses accrual difficulties of radiotherapy… Continue reading Accrual to Radiotherapy Trials in the US
How the scars of demolished brain tumors seed relapse
AI SummaryThe article discusses a study that found recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow from fibrous scars left behind by previous malignant brain tumors that were destroyed by interventions like radiotherapy, surgery, and immunotherapy. This discovery highlights how treatment-induced scarring can contribute to tumor relapse in GBM patients.A study has… Continue reading How the scars of demolished brain tumors seed relapse
[Articles] Palliative radiotherapy versus best supportive care in patients with painful hepatic cancer (CCTG HE1): a multicentre, open-label, randomised, controlled, phase 3 study
AI SummaryThe article discusses the findings of a study comparing palliative radiotherapy plus best supportive care to best supportive care alone in patients with painful hepatic cancer. The study concluded that single-fraction radiotherapy combined with best supportive care was more effective in improving pain control and could be considered a standard palliative treatment for these… Continue reading [Articles] Palliative radiotherapy versus best supportive care in patients with painful hepatic cancer (CCTG HE1): a multicentre, open-label, randomised, controlled, phase 3 study
Sociodemographic and geographic factors impacting radiotherapy recommendation, initiation, and completion for patients with cancer
AI SummaryThis article explores the impact of sociodemographic and geographic factors on the recommendation, initiation, and completion of radiotherapy for cancer patients. A retrospective patient cohort study examined patients diagnosed with common solid cancers from 2018 to 2021. Findings suggest that patients living further from treatment facilities, non-White patients, uninsured individuals, and those with lower… Continue reading Sociodemographic and geographic factors impacting radiotherapy recommendation, initiation, and completion for patients with cancer
Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy
AI SummaryThis article explores potential differences in organ preservation between total neoadjuvant therapy (TNT) regimens that use long-course chemoradiotherapy (LCCRT) versus short-course radiotherapy (SCRT) in rectal cancer. The study aims to define the impact of these treatment approaches on preserving organ function in rectal cancer patients. The results could have significant implications for improving patient… Continue reading Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy
Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More
AI SummaryThis article highlights the Editors’ Picks from August 2024 for the American Association for Cancer Research (AACR). The selections include topics such as a new metric called “Colon Age” for early-onset colorectal cancer screening, the relationship between exposure to neighborhood violence and glucocorticoid receptor signaling in lung tumors, and the development of a CD33-targeting… Continue reading Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More
Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT‐STS): Updated local control, late toxicities, and patient‐reported outcomes
AI SummaryThe study explored moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas, reporting on local control, late toxicities, and patient-reported outcomes. Results showed a 4-year local recurrence-free survival rate of 93%, few patients experiencing grade ≥2 toxicities, and improved functional outcomes and quality of life over time. The study indicates that this treatment… Continue reading Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT‐STS): Updated local control, late toxicities, and patient‐reported outcomes
Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT‐STS): Updated local control, late toxicities, and patient‐reported outcomes
AI SummaryThe study investigated moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas. Results showed a 4-year local recurrence-free survival rate of 93% with few patients experiencing grade ≥2 toxicities at 2 years. Functional outcomes and quality of life improved with time from treatment. The study suggests that this radiotherapy approach is safe and… Continue reading Moderately hypofractionated, preoperative radiotherapy in patients with soft tissue sarcomas (HYPORT‐STS): Updated local control, late toxicities, and patient‐reported outcomes
Thyroid Cancer: Playing ‘Molecular Chess’ Against a Grandmaster
AI SummaryThis article discusses the complexities of treating thyroid cancer, likening it to a game of “molecular chess” where cancer cells employ various defense strategies against treatments. It emphasizes the importance of molecular profiling and biomarking in anticipating and overcoming these defense mechanisms. Specific focus is placed on targeting mutations in the BRAF gene as… Continue reading Thyroid Cancer: Playing ‘Molecular Chess’ Against a Grandmaster