Tag: Protein Structure and Function

Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export

ABCC1 mediates the export of cGAMP, but the underlying molecular mechanism of cGAMP recognition and export is not clear. Here, Shinde et al. show that human ABCC1 forms a dimer in vitro and in vivo. Cryo-EM structures of ligand-free and cGAMP-bound ABCC1 reveal the molecular basis of cGAMP recognition and export.

Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors

Background Immune checkpoint inhibitors (ICIs) are recommended to treat patients with deficient mismatch repair/microsatellite instability high (dMMR/MSI-H) metastatic colorectal cancer (mCRC). Pivotal trials have fixed a maximum ICI duration of 2 years, without a compelling rationale. A shorter treatment duration has the potential to improve patients’ quality of life and reduce both toxicity and cost… Continue reading Early treatment discontinuation in patients with deficient mismatch repair or microsatellite instability high metastatic colorectal cancer receiving immune checkpoint inhibitors