Tag: Protein Structure and Function

Ventromedial hypothalamic nucleus neuronal nitric oxide knockdown effects on GABAergic neuron metabolic sensor and transmitter marker gene expression in the male rat

The diffusible gas nitric oxide (NO) and amino acid γ-gamma-aminobutyric acid (GABA) exert contrary effects on glucose counterregulation in the male rat, but how these neurochemical signals integrate within ve…

Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related deaths worldwide, especially in advanced stages where limited treatment options result in poor prognosis. The immunosuppressive tumor immune microenvironment (TIME), characterized by low immune cell infiltration and exhaustion, limits immunotherapy efficacy. To address this, our study investigates the role of C-C motif chemokine ligand 3… Continue reading Targeted delivery of CCL3 reprograms macrophage antigen presentation and enhances the efficacy of immune checkpoint blockade therapy in hepatocellular carcinoma

New microscope can image, at once, the full 3D orientation and position of molecules in cells

A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized fluorescence technology, a valuable tool for measuring the orientation of molecules, with a dual-view light sheet microscope (diSPIM), which excels at imaging along the depth (axial)… Continue reading New microscope can image, at once, the full 3D orientation and position of molecules in cells

Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors

E7766 is a novel stimulator of interferon genes (STING) agonist, capable of potent activation of immune cells and generating strong antitumor response in preclinical murine tumor models. Here we present the safety, efficacy, and biomarker results of the first-in-human phase I/Ib study of intratumoral E7766 in patients with advanced solid tumors. Eligible patients with relapsing/refractory… Continue reading Phase I dose-escalation and pharmacodynamic study of STING agonist E7766 in advanced solid tumors

Temporally Dissociable Neural Representations of Pitch Height and Chroma

The extraction and analysis of pitch underpin speech and music recognition, sound segregation, and other auditory tasks. Perceptually, pitch can be represented as a helix composed of two factors: height monotonically aligns with frequency, while chroma cyclically repeats at doubled frequencies. Although the early perceptual and neurophysiological mechanisms for extracting pitch from acoustic signals have… Continue reading Temporally Dissociable Neural Representations of Pitch Height and Chroma

xrRNAs adopt a long-lived conformation that prevents exonuclease activity

Biomolecules morph between conformations with distinct lifetimes according to their functional requirements. Mosquito-borne flaviviruses encode exoribonuclease-resistant RNAs (xrRNAs) that fold into knot-like structures to prevent exonuclease Xrn1 digestion. To achieve high Xrn1 resistance, xrRNAs contain molecular interactions with lifetimes that persist up to ten million times longer than canonical base pairs. This is a preview… Continue reading xrRNAs adopt a long-lived conformation that prevents exonuclease activity