AI SummaryB cells produce antibodies and can create a vast number of different antibodies by using portions of genes and mixing them up. A study using a mouse model found that changes in the genomic structure can allow B cells to produce diverse types of antibodies. The study also showed that genes can be combined… Continue reading How Genome Folding is Linked to Antibody Diversity
Tag: Protein Structure and Function
[ASAP] Ligand Control of Dinitrosyl Iron Complexes for Selective Superoxide-Mediated Nitric Oxide Monooxygenation and Superoxide–Dioxygen Interconversion
AI SummaryThe text is discussing the impact of climate change on bee populations and the potential consequences for food security. It suggests that the decline in bee populations may lead to declines in crop productivity and highlights the need for sustainable farming practices to mitigate these impacts.
Antiprogrammed death ligand 1 therapy failed to reduce the risk of developing brain metastases in patients with extensive‐stage small cell lung cancer: A retrospective analysis
AI SummaryImmunotherapy has shown promise in treating small cell lung cancer with brain metastases. However, immunotherapy did not delay brain progression or reduce the risk of metastasis in patients without baseline brain metastases. Overall survival was improved with immunotherapy regardless of the presence of brain metastases. These findings have important implications for the management of… Continue reading Antiprogrammed death ligand 1 therapy failed to reduce the risk of developing brain metastases in patients with extensive‐stage small cell lung cancer: A retrospective analysis
Antiprogrammed death ligand 1 therapy failed to reduce the risk of developing brain metastases in patients with extensive‐stage small cell lung cancer: A retrospective analysis
Abstract Background Immunotherapy (IO) has demonstrated promising results in treating extensive-stage small cell lung cancer (ES-SCLC), and the management of ES-SCLC brain metastases (BMs) is now receiving significant clinical attention. The objective of this study was to evaluate the role of IO in the clinical management of BMs. Methods Between January 2020 and December 2021,… Continue reading Antiprogrammed death ligand 1 therapy failed to reduce the risk of developing brain metastases in patients with extensive‐stage small cell lung cancer: A retrospective analysis
Editors’ Picks: Highlights from the AACR Journals
As you say farewell to summer, say hello to the latest installment of Editors’ Picks selected by the editors of the 10 AACR journals. This month’s selections include a drug that can help overcome resistance to several targeted therapies, an investigation of how tumor-derived extracellular vesicles inhibit CAR T-cell efficacy, a new type of bispecific… Continue reading Editors’ Picks: Highlights from the AACR Journals
Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis
Background anti-Programmed Death-1 (anti-PD-1) immunotherapy has shown promising manifestation in improving the survival rate of patients with advanced melanoma, with its efficacy closely linked to Programmed cell death-Ligand 1 (PD-L1) expression. However, low clinical efficacy and drug resistance remain major challenges. Although the metabolic alterations from tricarboxylic acid (TCA) cycle to glycolysis is a hallmark… Continue reading Inhibition of TCA cycle improves the anti-PD-1 immunotherapy efficacy in melanoma cells via ATF3-mediated PD-L1 expression and glycolysis
Synaptotagmin-11 Inhibits Synaptic Vesicle Endocytosis via Endophilin A1
AI SummarySynaptic vesicle (SV) endocytosis is an important process for maintaining neurotransmission. The absence of synaptotagmin-11 (Syt11) accelerates SV endocytosis and leads to abnormal distribution of synaptic proteins. Syt11 interacts with endophilin A1 (EndoA1), inhibiting its function and ensuring the precision of protein retrieval during SV endocytosis. Synaptic vesicle (SV) endocytosis is a critical and… Continue reading Synaptotagmin-11 Inhibits Synaptic Vesicle Endocytosis via Endophilin A1
[ASAP] Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7
Protein conformational ensembles in function: roles and mechanisms
The sequence-structure-function paradigm has dominated twentieth century molecular biology. The paradigm tacitly stipulated that for each sequence there exists a single, well-organized protein structure. Yet, to sustain cell life, function requires (i) that there be more than a single structure, (ii) that there be switching between the structures, and (iii) that the structures be incompletely… Continue reading Protein conformational ensembles in function: roles and mechanisms
[Newsdesk] Research in brief
Antibodies isolated from the blood of a patient who recovered from SARS and was also vaccinated against COVID-19 were found to neutralise almost all related coronaviruses . The combination of prior infection and vaccination raises the possibility of pan-coronavirus vaccines .