Protein Structure and Function

[ASAP] Cobalt-Catalyzed Asymmetric Hydrogenation of Ketones Enabled by the Synergism of an N–H Functionality and a Redox-Active Ligand

Symmetry model sheds light on the chemistry surrounding peptide helices

AI Summarystudy reveals the importance of symmetry and chirality in peptide helices, shedding light on how specific amino acid sequences influence the formation and properties of these structures. The research provides a new model for understanding the relationships between different helical conformations, offering insights into the chemistry surrounding peptide helices and their impact on protein… Continue reading Symmetry model sheds light on the chemistry surrounding peptide helices

Safety and clinical activity of BMS-986365 (CC-94676), a dual androgen receptor ligand-directed degrader and antagonist, in heavily pretreated patients with metastatic castration-resistant prostate cancer

AI SummaryIn this study, the safety and clinical activity of BMS-986365 (CC-94676), a dual androgen receptor ligand-directed degrader and antagonist, is examined in heavily pretreated patients with metastatic castration-resistant prostate cancer (mCRPC). The drug targets the androgen receptor via a unique mechanism of AR degradation and antagonism. The study, known as CC-94676-PCA-001 (NCT04428788), is a… Continue reading Safety and clinical activity of BMS-986365 (CC-94676), a dual androgen receptor ligand-directed degrader and antagonist, in heavily pretreated patients with metastatic castration-resistant prostate cancer

Biological condensates affect cellular behavior on a global scale

AI SummaryThis article discusses how biological condensates, which are structures inside cells formed without a membrane, can affect cellular behavior on a global scale. Previous research focused on their immediate impacts, but a new study shows that they can modulate internal electrochemistry and influence traits such as antibiotic resistance. Most biological chemistry research has historically… Continue reading Biological condensates affect cellular behavior on a global scale

Researchers explain the organization of DNA in chromosomes from repetitive interactions between nucleosomes

AI SummaryThis article discusses the organization of DNA in chromosomes, emphasizing repetitive interactions between nucleosomes as essential for this organization. The study highlights the importance of considering physical problems in DNA packaging in structural models of chromosomes and demonstrates that the multilaminar organization of DNA is compatible with the structural and functional properties of chromosomes.… Continue reading Researchers explain the organization of DNA in chromosomes from repetitive interactions between nucleosomes

Understudied protein blobs have global effects on cell biochemistry

AI SummaryThis article discusses the importance of biological condensates in controlling internal cell biochemistry. These structures, which form compartments in cells without a membrane boundary, can affect protein and molecule activity, as well as provide an alternative energy source for biological processes. The study reveals that these condensates have global effects on cell biochemistry, impacting… Continue reading Understudied protein blobs have global effects on cell biochemistry

[ASAP] A General Enantioselective α-Alkyl Amino Acid Derivatives Synthesis Enabled by Cobalt-Catalyzed Reductive Addition

Catchers of folding gone awry: a tale of small heat shock proteins

Party with a Purpose Honors Former Mayor and Prostate Cancer Advocate Michael Nutter

Between his nearly 15 years as a Philadelphia city councilmember (from 1992 to 2006) and two terms as mayor (from 2008 to 2016), Michael A. Nutter helped expand the smoking ban to more public buildings, decrease homicides by around 30%, launch a low-income friendly bike share system, increase high school graduation and college degree attainment… Continue reading Party with a Purpose Honors Former Mayor and Prostate Cancer Advocate Michael Nutter

RNA folding at low temperatures sheds light on primordial biochemistry

An artistic representation of the temperature dependence of the RNA free-energy landscape (FEL) of folding. The authors showed that RNAs undergo a phase transition in the cold and misfold due to the FEL changing with temperature. Upon lowering the temperature, the smooth desertic landscape where the system readily finds the energy global minimum to fold… Continue reading RNA folding at low temperatures sheds light on primordial biochemistry