AI SummaryThe study examined the association between ambient PM2.5 exposure and survival in children with cancer in the United States. Data showed that residing in areas with high air pollution levels was linked to worse overall survival, even at levels below EPA standards. This highlights the importance of setting appropriate air quality standards to safeguard… Continue reading Ambient air pollution and survival in childhood cancer: A nationwide survival analysis
Tag: Pediatric Cancer
Improved chemokine homing enhances CAR T–cell therapy for osteosarcoma
AI SummaryThis research focuses on improving CAR T-cell therapy for osteosarcoma by modifying the CAR T cells to express receptors that can recognize chemokines secreted by the tumor. This chemokine/chemokine receptor mismatch was identified as a challenge in current CAR T-cell therapy for osteosarcoma. The modification of CAR T cells to express CXCR2 or CXCR6… Continue reading Improved chemokine homing enhances CAR T–cell therapy for osteosarcoma
Drug developed for pancreatic cancer shows promise against most aggressive form of medulloblastoma
AI SummaryThe drug developed for pancreatic cancer has shown promising results in increasing symptom-free survival in preclinical models of the most aggressive form of medulloblastoma. This development suggests potential effectiveness in treating medulloblastoma without toxicity.A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models… Continue reading Drug developed for pancreatic cancer shows promise against most aggressive form of medulloblastoma
From the Bench, July 2024: Fighting Chemo Brain With Light, Controlling Cancer Cell Death, and More
AI SummaryThis piece highlights several cutting-edge cancer research studies, including the use of audiovisual pulses to combat “chemo brain,” the development of a system to control cancer cell death pathways, a virus-inspired delivery system for treating lung tumors, a more accurate humanized mouse model, the creation of “mini-colons” to study cancer initiation, and a cancer… Continue reading From the Bench, July 2024: Fighting Chemo Brain With Light, Controlling Cancer Cell Death, and More
Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial
AI SummaryThis study evaluated the use of reduced dose alkylator chemotherapy combined with radiotherapy for standard risk nonalveolar rhabdomyosarcoma in children and adolescents. The research found that a lower dose of alkylator chemotherapy along with radiotherapy achieved a 5-year overall survival rate of 93.7%. Adjuvant radiotherapy improved event-free survival but did not significantly impact overall… Continue reading Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial
Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial
AI SummaryThis study from the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG) evaluated reduced-dose alkylator chemotherapy combined with radiotherapy for standard-risk nonalveolar rhabdomyosarcoma (NA-RMS) in children and adolescents. Localized node-negative NA-RMS patients received specific cycles of chemotherapy with or without radiotherapy, and the primary endpoints were event-free survival (EFS) and overall survival (OS). Results… Continue reading Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial
Old Dogs Can Teach Cancer Researchers New Tricks
AI SummaryThe article discusses how dogs with cancer can serve as valuable models for studying cancer biology and assessing new treatments, with insights that can inform new approaches for treating cancer in humans. Dogs offer comparable tumor characteristics, immune systems, and exposure-driven cancers to humans, making them ideal subjects for research. Canine clinical trials, supported… Continue reading Old Dogs Can Teach Cancer Researchers New Tricks
Editors’ Picks, July 2024: Risks of CAR T-cell Therapy, Sarcoma Advances, and More
AI SummaryThis article presents the Editors’ Picks for July 2024, highlighting advancements in cancer research including risks associated with CAR T-cell therapy and sarcoma treatment. Key points include a review of secondary malignancies after CAR-T cell therapy, a study on oncogenic signaling pathways as a treatment strategy, optimization of screening strategies for nasopharyngeal carcinoma, and… Continue reading Editors’ Picks, July 2024: Risks of CAR T-cell Therapy, Sarcoma Advances, and More
rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors
AI SummaryThe study explores the potential of combining CAR-T cell therapy with an engineered long-acting interleukin-7 (rhIL-7-hyFc or NT-I7) to enhance efficacy against solid tumors. Results showed regression of solid tumors, improved T-cell expansion, reduced exhaustion markers, and increased generation of memory CAR-T cells when combined with NT-I7 compared to IL-2. The STAT5 pathway was… Continue reading rhIL-7-hyFc, a long-acting interleukin-7, improves efficacy of CAR-T cell therapy in solid tumors
Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma
AI SummaryThis study focused on utilizing B7-H3 chimeric antigen receptor (CAR) T cells that express the Interleukin-8 (IL-8) receptor, CXCR2, to enhance homing and cytotoxicity in sarcomas like rhabdomyosarcoma and osteosarcoma. Results showed that B7-H3 CXCR2 CAR T cells had increased tumor homing, metabolic activity, and led to significant tumor regression in IL-8 expressing tumors.… Continue reading Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma