AI SummaryThis article discusses the use of combinatorial innate immunotherapy to overcome resistance within the Ewing sarcoma microenvironment. The study shows that a chimeric antigen receptor (CAR) NK cell targeting MCAM, combined with NKTR-255 (IL-15 agonist) and Magrolimab (CD47 blockade), significantly enhances NK cell cytotoxicity and macrophage phagocytic activity against ES cells. Results from in… Continue reading Circumventing resistance within the Ewing sarcoma microenvironment by combinatorial innate immunotherapy
Tag: Pediatric Cancer
Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More
AI SummaryThis article highlights the Editors’ Picks from August 2024 for the American Association for Cancer Research (AACR). The selections include topics such as a new metric called “Colon Age” for early-onset colorectal cancer screening, the relationship between exposure to neighborhood violence and glucocorticoid receptor signaling in lung tumors, and the development of a CD33-targeting… Continue reading Editors’ Picks, August 2024: ‘Colon Age’ Screening Recs, Stress From Violence, and More
[ASAP] Injectable Dendrimer Hydrogel Delivers Melphalan in Both Conjugated and Free Forms for Retinoblastoma
BiomacromoleculesDOI: 10.1021/acs.biomac.4c00597
Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board
AI SummaryThis article discusses consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma (ES) based on discussions by the National Ewing Sarcoma Tumor Board. It covers topics such as the initial approach to patients with relapsed ES, the role of molecular testing, chemotherapy regimens, maintenance therapy, and high-dose chemotherapy with autologous stem… Continue reading Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board
Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board
AI SummaryThe article discusses consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma, a type of cancer that commonly affects children, adolescents, and young adults. The recommendations are based on discussions by the National Ewing Sarcoma Tumor Board, which focuses on challenging cases of ES. Topics covered include the initial approach to… Continue reading Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board
Continuity and coordination of care for childhood cancer survivors with multiple chronic conditions: Results from the Childhood Cancer Survivor Study
AI SummaryThis study focuses on the continuity and coordination of care for childhood cancer survivors with multiple chronic conditions. Results from the survey showed that care discontinuity is prevalent among survivors, especially among younger individuals. Seeing a cancer specialist as the main provider was associated with less discontinuity, while shorter durations of care with the… Continue reading Continuity and coordination of care for childhood cancer survivors with multiple chronic conditions: Results from the Childhood Cancer Survivor Study
Continuity and coordination of care for childhood cancer survivors with multiple chronic conditions: Results from the Childhood Cancer Survivor Study
AI SummaryThe study focused on continuity and coordination of care for childhood cancer survivors with multiple chronic conditions. A survey was conducted among participants with two or more chronic conditions to assess perceived continuity of care from multiple clinicians. The results showed that care discontinuity is prevalent among childhood cancer survivors, with younger survivors more… Continue reading Continuity and coordination of care for childhood cancer survivors with multiple chronic conditions: Results from the Childhood Cancer Survivor Study
New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered
AI SummaryScientists from St. Jude Children’s Research Hospital, Seattle Children’s, and COG have identified new genetic variations that influence relapse risk in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL). This discovery could lead to improved diagnosis, tailored treatment, and potentially novel approaches in managing the disease. Previous studies had primarily focused on… Continue reading New genomic predictors of relapse in childhood B-cell acute lymphoblastic leukemia uncovered
Scientists identify genes linked to relapse in the most common form of childhood leukemia
AI SummaryThis article discusses how scientists have identified genetic variations that affect the risk of relapse in children with standard risk B-cell acute lymphoblastic leukemia (SR B-ALL), the most common form of childhood cancer. This research could potentially lead to improved treatments and outcomes for children with this type of leukemia.Scientists have identified novel genetic… Continue reading Scientists identify genes linked to relapse in the most common form of childhood leukemia
Ambient air pollution and survival in childhood cancer: A nationwide survival analysis
AI SummaryThis study examines the impact of ambient PM2.5 exposure on survival in children with cancer in the United States, finding that higher levels of PM2.5 are associated with worse overall survival, even below EPA standards. The research highlights the importance of establishing appropriate air quality standards to safeguard the health of this vulnerable population.Abstract… Continue reading Ambient air pollution and survival in childhood cancer: A nationwide survival analysis