AbbVie’s experimental drug to treat early Parkinson’s disease helped significantly improve patients’ ability to carry out daily tasks such as eating and walking, months… Reuters Health Information
Tag: Parkinson’s Disease
[ASAP] Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson’s Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin
Hearing Loss, Incident Parkinson Disease, and Treatment With Hearing Aids
This cohort study analyzes electronic health record data for US veterans with an audiogram to determine whether hearing loss is associated with an increased risk of Parkinson disease and to gauge its effect modification by well-established prodromal conditions and hearing aids.
Eosinophilic Esophagitis Drives Tissue Fibroblast Regenerative Programs Towards Pathologic Dysfunction
NOTCH2NLC GGC intermediate repeat with serine induces hypermyelination and early Parkinson’s disease-like phenotypes in mice
The expansion of GGC repeats (typically exceeding 60 repeats) in the 5’ untranslated region (UTR) of the NOTCH2NLC gene (N2C) is linked to N2C-related repeat expansion disorders (NREDs), such as neuronal intranuc…
Wearable Devices for Parkinson’s Disease: The Future Is Here
Wearable devices once seemed futuristic for Parkinson’s disease. Today, tools like activity trackers, tremor gloves, and laser canes are transforming the management of the disease. Medscape Medical News
The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B (catB) are associated with increased risk of Parkinson’s disease (PD). However, neither the specific CTSB variants driving these associations…
Nuclear pore and nucleocytoplasmic transport impairment in oxidative stress-induced neurodegeneration: relevance to molecular mechanisms in Pathogenesis of Parkinson’s and other related neurodegenerative diseases
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope and facilitate the exchange of macromolecules between the nucleus and cytoplasm in eukaryotic cells. The dysfunction of the NPC and nuclear tr…
Food as Medicine: Diet’s Role in Parkinson’s Disease
Diet is increasingly being researched as a potential intervention to slow, or even prevent, neurodegeneration in Parkinson’s disease. Medscape Medical News
[Review] Multiple system atrophy: advances in pathophysiology, diagnosis, and treatment
Multiple system atrophy is an adult-onset, sporadic, and progressive neurodegenerative disease. People with this disorder report a wide range of motor and non-motor symptoms. Overlap in the clinical presentation of multiple system atrophy with other movement disorders (eg, Parkinson’s disease and progressive supranuclear palsy) is a concern for accurate and timely diagnosis. Over the past… Continue reading [Review] Multiple system atrophy: advances in pathophysiology, diagnosis, and treatment