Tag: Parkinson’s Disease

New protein target offers promise for alleviating cognitive decline in Parkinson’s disease

A recently published study by researchers at the University of Arizona Health Sciences found that a tiny protein called PNA5 appears to have a protective effect on brain cells, which could lead to treatments for the cognitive symptoms of Parkinson’s disease and related disorders. Parkinson’s disease, a neurological disorder best known for causing tremors, stiffness,… Continue reading New protein target offers promise for alleviating cognitive decline in Parkinson’s disease

Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, characterized by the presence of extracellular amyloid plaques consisting of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau (pTau) protein in the brain. Genetic and animal studies strongly indicate that Aβ, tau and neuroinflammation play important roles in the pathogenesis of AD. Several… Continue reading Strategies of positron emission tomography (PET) tracer development for imaging of tau and α-synuclein in neurodegenerative disorders

Gastrointestinal tract cleavage of α-synuclein by asparaginyl endopeptidase leads to Parkinson’s disease

Pathologic α-synuclein (α-syn) aggregates from the gastrointestinal (GI) tract may contribute to Parkinson’s disease (PD). Xiang et al. report in Neuron that enteric nervous system-specific expression of asparaginyl endopeptidase (AEP)-truncated α-syn and tau spreads to the brain, synergistically causing PD-related neurodegeneration and neurobehavioral deficits.

1205 AI-informed integration of spatial architecture of collagen and tumor-infiltrating lymphocytes from H&E images predicts response to immunotherapy in head and neck squamous cell carcinoma patients

Background Even though immune checkpoint inhibitors have improved survival rates for patients with recurrent and/or metastatic head and neck squamous cell carcinoma (HNSCC), a significant number of patients do not show durable responses. Previous studies have described correlation between overall survival and features derived from both collagen fibers and spatial arrangement of tumor-infiltrating lymphocytes (TILs)… Continue reading 1205 AI-informed integration of spatial architecture of collagen and tumor-infiltrating lymphocytes from H&E images predicts response to immunotherapy in head and neck squamous cell carcinoma patients

1159 iPSC-derived organoids for organ-specific disease modeling and toxicity screening

Background Current organoid technologies are a promising advancement in drug development and disease modeling, designed to combat the increasingly high clinical drug failure rates despite rigorous conventional preclinical testing. Organoids have been considered as a gold standard for preclinical drug development: providing a model that has a human genomic background, mimics the 3D architecture and… Continue reading 1159 iPSC-derived organoids for organ-specific disease modeling and toxicity screening

972 A neuroinflammation screening cascade to facilitate novel drug discovery

Background Neuroinflammation is an immune response activated by microglia and astrocytes in the central nervous system (CNS), it is not only a result of neurodegeneration but also a crucial player in this process. the secretion of inflammatory factors in neuroinflammation mainly comes from microglia and astrocytes, and activated microglia and astrocytes are present in almost… Continue reading 972 A neuroinflammation screening cascade to facilitate novel drug discovery

209 Spatial multi-omics reveal humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer pathologic responders to neoadjuvant immunotherapy

Background Tertiary lymphoid structures (TLS) are tissue-embedded organized immune cellular neighborhoods frequently associated with higher survival in many cancers.1 In pancreatic adenocarcinoma (PDAC), intratumoral TLS enrichment has been associated with rare long-term survivors.2 Cancer vaccines have been used to induce intratumoral TLS in PDAC in an effort to improve outcomes.3 Nonetheless, the immunosuppressive landscape of… Continue reading 209 Spatial multi-omics reveal humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer pathologic responders to neoadjuvant immunotherapy