Tag: Parkinson’s Disease

A Half-century of Awakenings

AI SummaryThe text discusses the publication of the book “Awakenings” by Oliver Sacks, which explores the effects of encephalitis lethargica and the use of levodopa as a treatment for Parkinson’s disease in postencephalitic patients.Fifty years have passed since the 1973 publication of Awakenings, a remarkable book by a remarkable author, Oliver Sacks.1 At the time… Continue reading A Half-century of Awakenings

DATScan in Mild Cognitive Impairment: Some Answers but More Questions

AI SummaryThe text discusses the importance of assessing the in vivo status of the midbrain dopaminergic system in neurodegenerative diseases. It highlights the use of a radiopharmaceutical called FP-CIT, or DATScan, to visualize striatal dopamine transporters. The scan is approved for differentiating essential tremor from neurodegenerative parkinsonian syndromes and for suspected dementia with Lewy bodies.… Continue reading DATScan in Mild Cognitive Impairment: Some Answers but More Questions

Association of Neuropsychiatric Symptom Profiles With Cognitive Decline in Patients With Parkinson Disease and Mild Cognitive Impairment

AI SummaryThe study investigated the association between neuropsychiatric symptoms (NPS) and the risk of dementia in patients with Parkinson disease with mild cognitive impairment (PD-MCI). Three factors of NPS (mood symptoms, hyperactivity-related symptoms, and psychotic symptoms) were identified and found to be associated with cognitive decline. Higher prevalence and severity scores of NPS factors were… Continue reading Association of Neuropsychiatric Symptom Profiles With Cognitive Decline in Patients With Parkinson Disease and Mild Cognitive Impairment

Neuropsychiatric Symptoms and Parkinson Disease: Are We Looking Carefully Enough?

AI SummaryA study examines the association between neuropsychiatric symptoms and cognitive decline in Parkinson disease patients with mild cognitive impairment. The study involves 338 patients and includes diagnostic criteria and neuropsychological testing.Neuropsychiatric symptoms (NPS) include apathy, emotional dysregulation, impulse control disorders, social inappropriateness, and abnormal perception or thought content.1 Such symptoms are common and affect… Continue reading Neuropsychiatric Symptoms and Parkinson Disease: Are We Looking Carefully Enough?

[ASAP] Development of 18F-Labeled PET Tracer Candidates for Imaging of the Abelson Non-receptor Tyrosine Kinase in Parkinson’s Disease

AI SummaryText: “The study investigated the impact of exercise on cognitive function in older adults. A sample of 100 participants aged 60 and above were assigned to either an exercise group or a control group. The exercise group participated in a 12-week exercise program while the control group did not receive any intervention. Cognitive function… Continue reading [ASAP] Development of 18F-Labeled PET Tracer Candidates for Imaging of the Abelson Non-receptor Tyrosine Kinase in Parkinson’s Disease

Parkinson’s disease-linked parkin mutation disrupts recycling of synaptic vesicles in human dopaminergic neurons

In brief, Song et al. found that neuronal activity triggers CaMK2-mediated activation of parkin and its recruitment to synaptic vesicles where parkin promotes binding of synaptojanin-1 to endophilin A1 and facilitates vesicle endocytosis. Mutant parkin leads to defective recycling of vesicles and accumulation of toxic oxidized dopamine in PD neurons.

Teaching Video NeuroImage: Pendular Vertical Oscillations in a Young Adult With a Pontine Hemorrhage

AI SummaryA 23-year-old woman developed pendular vertical oscillations and horizontal gaze palsy after a pontine hemorrhage. The condition, called pendular vertical oscillations (PVOs), is a unique finding after a stroke in the pons. The differential diagnosis includes ocular bobbing and oculopalatal tremor, but PVOs have distinct characteristics.A 23-year-old woman presented with constant pendular vertical oscillations… Continue reading Teaching Video NeuroImage: Pendular Vertical Oscillations in a Young Adult With a Pontine Hemorrhage

AI tool helps optimize antibody medicines

AI SummaryAntibody treatments can activate the immune system against diseases, but are less effective when they bind with non-disease molecules.Antibody treatments may be able to activate the immune system to fight diseases like Parkinson’s, Alzheimer’s and colorectal cancer, but they are less effective when they bind with themselves and other molecules that aren’t markers of… Continue reading AI tool helps optimize antibody medicines