A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called “chaperones” are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such as Alzheimer’s and Parkinson’s along with many others, can occur. The team’s research provides a new… Continue reading The crucial role of ‘chaperones’ in maintaining neuronal function
Tag: Parkinson’s Disease
Researchers highlight role ‘workhorse protein’ plays in keeping nervous system running smoothly
Correction: The Parkinson’s disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons
Peptide-guided nanoparticles deliver mRNA to neurons
Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.
‘Chance Finding’ a True Breakthrough for Spinal Cord Injury?
Deep brain stimulation of the lateral hypothalamus improves walking and promotes recovery in patients with spinal cord injury, new research showed. Medscape Medical News
Penn-led consortium to advance imaging of brain diseases
A Penn Medicine-led consortium of radiology and chemistry researchers across the United States will advance imaging of diseases like Parkinson’s by testing radiotracers they identified that illuminate α-synuclein (αSyn) or 4R tau proteins on positron emission tomography (PET) scans. Armed with a five-year, $30 million grant from the National Institutes of Neurological Disease and Stroke,… Continue reading Penn-led consortium to advance imaging of brain diseases
[ASAP] Biomimetic Approach for Optimal Designing of the Shape and Controlled Release of Therapeutics from Tricompartmental Microcarriers for Managing Parkinson’s Disease
ACS Applied Bio MaterialsDOI: 10.1021/acsabm.4c01149
AbbVie’s Parkinson’s Disease Drug Improves Patient Mobility in Late-stage Study
AbbVie’s experimental drug to treat early Parkinson’s disease helped significantly improve patients’ ability to carry out daily tasks such as eating and walking, months… Reuters Health Information
[ASAP] Exploring Cimetidine as a Potential Therapeutic Attenuator against Amyloid Formation in Parkinson’s Disease: Spectroscopic and Microscopic Insights into Alpha-Synuclein and Human Insulin
Hearing Loss, Incident Parkinson Disease, and Treatment With Hearing Aids
This cohort study analyzes electronic health record data for US veterans with an audiogram to determine whether hearing loss is associated with an increased risk of Parkinson disease and to gauge its effect modification by well-established prodromal conditions and hearing aids.