Parkinson’s disease (PD) is a neurodegenerative disorder characterized by protein aggregates mostly consisting of misfolded alpha-synuclein (αSyn). Progressive degeneration of midbrain dopaminergic neurons (mD…
Tag: Parkinson’s Disease
[ASAP] m6A Demethylase FTO-Mediated Upregulation of BAP1 Induces Neuronal Ferroptosis via the p53/SLC7A11 Axis in the MPP+/MPTP-Induced Parkinson’s Disease Model
Emerging targets of α-synuclein spreading in α-synucleinopathies: a review of mechanistic pathways and interventions
α-Synucleinopathies constitute a spectrum of neurodegenerative disorders, including Parkinson’s disease (PD), Lewy body dementia (LBD), Multiple System Atrophy (MSA), and Alzheimer’s disease concurrent with LB…
[ASAP] Network-Based Drug Optimization toward the Treatment of Parkinson’s Disease: NRF2, MAO-B, Oxidative Stress, and Chronic Neuroinflammation
The Year in Parkinson’s Disease 2024
Drs Indu Subramanian and Alfonso Fasano discuss some of the 2024 highlights in Parkinson’s disease research, including a paradigm shift in diagnosis and the potential role of GLP-1s. Medscape Neurology
Positron emission tomography tracers for synucleinopathies
Synucleinopathies, such as Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, are characterized by the aggregation of α-synuclein. Variations in brain distribution allow for different…
Optogenetic Control of Dopamine Receptor 2 Reveals a Novel Aspect of Dopaminergic Neurotransmission in Motor Function
Dopaminergic neurotransmission plays a crucial role in motor function through the coordination of dopamine receptor (DRD) subtypes, such as DRD1 and DRD2, thus the functional imbalance of these receptors can lead to Parkinson’s disease. However, due to the complexity of dopaminergic circuits in the brain, it is limited to investigating the individual functions of each… Continue reading Optogenetic Control of Dopamine Receptor 2 Reveals a Novel Aspect of Dopaminergic Neurotransmission in Motor Function
Peptide-based amyloid-beta aggregation inhibitors
Aberrant protein misfolding and accumulation is considered to be a major pathological pillar of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Aggregation of amyloid-β (Aβ) peptide leads to the formation of toxic amyloid fibrils and is associated with cognitive dysfunction and memory loss in Alzheimer’s disease (AD). Designing molecules that inhibit amyloid aggregation seems to… Continue reading Peptide-based amyloid-beta aggregation inhibitors
[ASAP] Microstructural Degeneration of the Corpus Callosum in Parkinson’s Disease with Unilateral Onset: A Free-Water Imaging Study
Structural-functional connectivity decoupling in multiscale brain networks in Parkinson’s disease
Parkinson’s disease (PD) is a progressive neurodegenerative disease associated with functional and structural alterations beyond the nigrostriatal dopamine projection. However, the structural-functional (SC-FC…