CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

INTRODUCTIONThe ability of HIV-1 to persist within infected cells as an integrated provirus, even during suppressive antiretroviral therapy (ART), represents the main barrier to achieve ART-free HIV remission or cure (1, 2). Various strategies to inactivate or eliminate latent viral reservoirs have been proposed, many of which involve approaches to modulate proviral expression (1, 3).… Continue reading CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells