Tag: Oncogenic Viruses

Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication

Olagnier D, Farahani E, Thyrsted J, Blay-Cadanet J, Herengt A, Idorn M, Hait A, Hernaez B, Knudsen A, Iversen MB, Schilling M, Jørgensen SE, Thomsen M, Reinert LS, Lappe M, Hoang H-D, Gilchrist VH, Hansen AL, Ottosen R, Nielsen CG, Møller C, van der Horst D, Peri S, Balachandran S, Huang J, Jakobsen M, Svenningsen… Continue reading Oxidative stress sensor Keap1 recognizes HBx protein to activate the Nrf2/ARE signaling pathway, thereby inhibiting hepatitis B virus replication

Kaposi’s sarcoma-associated herpesvirus glycoprotein K8.1 is critical for infection in a cell-specific manner and functions at the attachment step on keratinocytes

ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with Kaposi’s sarcoma and B cell malignancies. K8.1, the major antigenic component of the KSHV virion, has been reported to play a critical role in the infection of B cells, but otherwise its function remains enigmatic. We created a K8.1 knockout virus (KSHVΔK8.1) in the BAC16 genetic background… Continue reading Kaposi’s sarcoma-associated herpesvirus glycoprotein K8.1 is critical for infection in a cell-specific manner and functions at the attachment step on keratinocytes

Nasopharyngeal cancer screening with an anti-BNLF2b antibody: a new arrow in the quiver?

Epstein–Barr virus (EBV)-based biomarkers are used for nasopharyngeal carcinoma (NPC) screening in endemic regions. A recent prospective study describes the use of a new serological biomarker, antibodies targeting the EBV protein BNLF2b, for NPC screening in >20,000 participants. This biomarker yielded both higher sensitivity and specificity for NPC detection in the screening cohort compared with… Continue reading Nasopharyngeal cancer screening with an anti-BNLF2b antibody: a new arrow in the quiver?

Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection

INTRODUCTIONHepatitis B virus (HBV) is a DNA virus that infects over 360 million people worldwide, despite an available vaccine. Current treatment options for HBV infection are limited and rarely result in clearance (1). Hepatitis C virus (HCV) is an RNA virus that infects 71 million people worldwide, with no available vaccine but successful treatment options… Continue reading Activation of AIM2 by hepatitis B virus results in antiviral immunity that suppresses hepatitis C virus during coinfection

Single-molecule-binding studies of antivirals targeting the hepatitis C virus core protein

Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Žídek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein… Continue reading Single-molecule-binding studies of antivirals targeting the hepatitis C virus core protein

AACR Special Conferences Gather Investigators Advancing Research on Gynecologic Cancers  

AI SummaryBased on estimates from the National Cancer Institute, over 110,000 cases of gynecologic cancers will be diagnosed in the U.S. in 2023, resulting in approximately 34,000 deaths. Gynecologic cancers include cervical, ovarian, vaginal, vulvar, and uterine cancer. Risk factors include older age, obesity, family history, genetic mutations, and HPV infection. Research advances have led… Continue reading AACR Special Conferences Gather Investigators Advancing Research on Gynecologic Cancers  

Conditional replication and secretion of hepatitis B virus genome uncover the truncated 3′ terminus of encapsidated viral pregenomic RNA

Department of Infectious Diseases, State Key Laboratory of Organ Failure Research, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Cancer Virology… Continue reading Conditional replication and secretion of hepatitis B virus genome uncover the truncated 3′ terminus of encapsidated viral pregenomic RNA