Jumper J, Evans R, Pritzel A, Green T, Figurnov M, Ronneberger O, Tunyasuvunakool K, Bates R, Žídek A, Potapenko A, Bridgland A, Meyer C, Kohl SAA, Ballard AJ, Cowie A, Romera-Paredes B, Nikolov S, Jain R, Adler J, Back T, Petersen S, Reiman D, Clancy E, Zielinski M, Steinegger M, Pacholska M, Berghammer T, Bodenstein… Continue reading Single-molecule-binding studies of antivirals targeting the hepatitis C virus core protein
Tag: Oncogenic Viruses
AACR Special Conferences Gather Investigators Advancing Research on Gynecologic Cancers
AI SummaryBased on estimates from the National Cancer Institute, over 110,000 cases of gynecologic cancers will be diagnosed in the U.S. in 2023, resulting in approximately 34,000 deaths. Gynecologic cancers include cervical, ovarian, vaginal, vulvar, and uterine cancer. Risk factors include older age, obesity, family history, genetic mutations, and HPV infection. Research advances have led… Continue reading AACR Special Conferences Gather Investigators Advancing Research on Gynecologic Cancers
Conditional replication and secretion of hepatitis B virus genome uncover the truncated 3′ terminus of encapsidated viral pregenomic RNA
Department of Infectious Diseases, State Key Laboratory of Organ Failure Research, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Cancer Virology… Continue reading Conditional replication and secretion of hepatitis B virus genome uncover the truncated 3′ terminus of encapsidated viral pregenomic RNA
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles
Zhang M, Zhang J, Tan Y, Xin Y, Gao H, Zheng S, Yi Y, Zhang J, Wu C, Zhao Y, Jin Z, Gao Z, Mao X, Wang M, Hu P, Rao H, Jia Z, Hou J, Chen L, Yang X, Lu J, Han T, Chen Y, Ning Q, Yang D, Shang J, Jiang J, He… Continue reading Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles
Genetic variation of E6 and E7 genes of human papillomavirus type 16 from central China
Persistent high-risk human papillomavirus (HR-HPV) infection is an important factor in the development of cervical cancer, and human papillomavirus type 16 (HPV-16) is the most common HR-HPV type worldwide. Th… Continue reading on BioMed Central
Bridging the Gap: Immunotherapy in Progressive Multifocal Leukoencephalopathy: A New Hope?
AI SummaryProgressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS caused by the JC virus. There is currently no effective antiviral treatment for PML, so boosting the immune response against the virus is important. A case is presented where a patient with PML after kidney transplantation received recombinant human interleukin 7 to enhance… Continue reading Bridging the Gap: Immunotherapy in Progressive Multifocal Leukoencephalopathy: A New Hope?
Unveiling the role of EBV in the onset and progression of multiple sclerosis
AI SummaryAn international research team is investigating the connection between the Epstein-Barr virus (EBV) and the development of multiple sclerosis (MS). They aim to understand why only some EBV-infected people develop MS, and to uncover the underlying mechanism. The team is conducting clinical trials to test antiviral therapies and will analyze blood and saliva samples.… Continue reading Unveiling the role of EBV in the onset and progression of multiple sclerosis
Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
AI SummaryThe text discusses the functions of the papillomavirus E2 protein, including its role in regulating viral replication, transcription, and plasmid segregation. The text also mentions the interaction between the E2 protein and host proteins during mitosis. Further research is needed to understand the plasmid segregation function of the E2 protein in human papillomavirus 16.INTRODUCTIONPapillomavirus… Continue reading Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function
The effect of hepatitis B virus on the risk of pregnancy outcomes: a systematic review and meta-analysis of cohort studies
AI SummaryThis text discusses the impact of chronic hepatitis B virus on neonatal and maternal outcomes and aims to determine its effect through a meta-analysis.The effect of HBV on neonatal and maternal outcomes can create a basis for more accurate clinical decision-making. So, the aim of this meta-analysis is to detrmine the effect of chronic… Continue reading The effect of hepatitis B virus on the risk of pregnancy outcomes: a systematic review and meta-analysis of cohort studies
Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1
Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu… Continue reading Epstein-Barr virus LMP1 enhances levels of large extracellular vesicle-associated PD-L1