Researchers found a reduction in cervical cancer mortality in women under the age of 25, which is likely due to the introduction of the HPV vaccine.
Tag: Oncogenic Viruses
The characterization and structural basis of a human broadly binding antibody to HBV core protein
Connecting the dots: Presentation of EBV antigens on HLA class II risk alleles connects the two main risk factors of multiple sclerosis
Study on the clinical characteristics, persistent infection capability and viral load of human papillomavirus type 26 single infection
Human papillomavirus (HPV) infection is the main cause of cervical cancer. Different types of HPV have varying carcinogenic capabilities, and viral load is one of the key indicators of pathogenicity. Currently… Continue reading on BioMed Central
[ASAP] The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075
Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy
Background Gastric carcinomas (GC) are aggressive malignancies, and only ~15% of patients respond to anti-programmed cell death (ligand) 1 (PD-(L)1) monotherapy. However, Epstein-Barr virus (EBV)-associated GCs (~5–10% of GCs) often harbor PD-L1 and PD-L2 chromosomal amplifications and robust CD8+ T cell infiltrates, and respond at a high rate to anti-PD-1. The current study compares the… Continue reading Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy
Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility
Abstract High-risk human papillomaviruses (HPVs) cause various cancers. While type-specific prophylactic vaccines are available, additional anti-viral strategies are highly desirable. Initial HPV cell entry involves receptor-switching induced by structural capsid modifications. These modifications are initiated by interactions with cellular heparan sulphates (HS), however, their molecular nature and functional consequences remain elusive. Combining virological assays with… Continue reading Glycan-induced structural activation softens the human papillomavirus capsid for entry through reduction of intercapsomere flexibility
Hepatitis B and D virus entry
Abstract Hepatitis B virus (HBV) entry is the initial step of viral infection, leading to the formation of covalently closed circular DNA, which is a molecular reservoir of viral persistence and a key obstacle for HBV cure. The restricted entry of HBV into specific cell types determines the nature of HBV, which has a narrow… Continue reading Hepatitis B and D virus entry
Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Advances in 2024 have transformed our understanding of CD8+ T cell dysfunction in chronic hepatitis B virus infection, revealing diverse T cell populations that defy the classic exhaustion model. Studies highlight new therapeutic strategies, such as 4-1BB agonism and TGFβ inhibition, that could rejuvenate these cells and restore antiviral function. Key advances Andreata et al.6… Continue reading Unlocking CD8+ T cell potential in chronic hepatitis B virus infection
Meta-analysis links high-risk Epstein-Barr virus lineage to nasopharyngeal cancer in southern China
Researchers have discovered a significant association between specific Epstein-Barr virus (EBV) variants and nasopharyngeal carcinoma (NPC). NPC is a cancer notably prevalent in southern China, where it is 20 times more common than in non-endemic regions of the world.