Immunotherapy’s “Sweet” Future: Wrapping up AACR IO 2025 With Glyco-immunology 

The closing keynote session of the inaugural AACR IO painted an exciting picture of the emerging frontier of glyco-immunology, with Jessica Stark, PhD, and Gabriel Rabinovich, PhD, highlighting the profound immunological influence of glycans and the potential power of targeting glyco-immune checkpoints. Earlier on the final day of the conference, held February 23-26 in Los… Continue reading Immunotherapy’s “Sweet” Future: Wrapping up AACR IO 2025 With Glyco-immunology 

The HPV Vaccine: Safe, Effective, Prevents Cancer

In the United States, human papillomavirus (HPV) is the most common sexually transmitted infection, according to the US Centers for Disease Control and Prevention (CDC). These infections are so common, it’s thought that almost all men and women will eventually get an infection with some kind of HPV. March 4 is International HPV Awareness Day.… Continue reading The HPV Vaccine: Safe, Effective, Prevents Cancer

The HPV Vaccine: Safe, Effective, Prevents Cancer

In the United States, human papillomavirus (HPV) is the most common sexually transmitted infection, according to the US Centers for Disease Control and Prevention (CDC). These infections are so common, it’s thought that almost all men and women will eventually get an infection with some kind of HPV. March 4 is International HPV Awareness Day.… Continue reading The HPV Vaccine: Safe, Effective, Prevents Cancer

Ubiquitin and ubiquitin-like proteins in HPV-driven carcinogenesis

Abstract Persistent infection with high-risk (HR) human papillomaviruses (HPVs) is responsible for approximately 5% of cancer cases worldwide, including a growing number of oropharyngeal and anogenital cancers. The major HPV oncoproteins, E6 and E7, act together to manipulate cellular pathways involved in the regulation of proliferation, the cell cycle and cell survival, ultimately driving malignant… Continue reading Ubiquitin and ubiquitin-like proteins in HPV-driven carcinogenesis

Activating transcription factor 3 induces oxidative stress and genotoxicity, transcriptionally modulating metastasis-related gene expression in human papillomavirus-infected cervical cancer

Activating Transcription Factor 3 (ATF3) is known for its tumor-suppressive properties in cervical cancer, particularly through its role in stress response and interactions with human papillomavirus (HPV) onco… Continue reading on BioMed Central

Discovery paves way for new hepatitis B treatment

In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by Memorial Sloan Kettering Cancer Center (MSK), Weill Cornell Medicine, and The Rockefeller University identified a vulnerability that opens the door to new treatments. The team successfully disrupted the… Continue reading Discovery paves way for new hepatitis B treatment

Editors’ Picks, February 2025: Improving CAR T, Studying Breast Cancer Risk, and More

Cover of Blood Cancer Discovery depicting how CAR T cells using various combinations of chimeric receptors may improve specificity and limit toxicity through the creation of logic-gated circuits. As we close out the month of love, the Cancer Research Catalyst staff (chiefly based in the City of Brotherly Love) is not so secretly admiring this… Continue reading Editors’ Picks, February 2025: Improving CAR T, Studying Breast Cancer Risk, and More