Researchers have demonstrated that self-sampling is just as effective as speculum-based testing for HPV detection.
Tag: Oncogenic Viruses
Gene therapy shows clinical benefit in patients with a debilitating disorder caused by HPV
An NCI clinical trial showed that an experimental gene therapy called PRGN-2012 may be an effective treatment for recurrent respiratory papillomatosis, which is caused by HPV 6 and HPV 11.
Prevalence of hepatitis B virus infection and associated factors among adults intrafamilial household contacts attending antenatal care clinics in the Central Ethiopian region: from pregnant women index cases
In Ethiopia, hepatitis B virus infections are prevalent and highly endemic. Additionally, there has been a significant increase in hospital admissions, morbidity, and mortality associated with hepatitis B viru… Continue reading on BioMed Central
Unexpected HBsAg decrease after nucleoside analogues retreatment among HBeAg positive postpartum women: a pilot study
Mother-to-child transmission (MTCT) is one of the main routes of transmission of HBV, and previous studies focused on the efficacy and safety of nucleoside analogues (NAs) in preventing MTCT. There are limited… Continue reading on BioMed Central
IFI16 recruits HDAC1 and HDAC2 to deacetylate the Kaposi’s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA), facilitating latency
Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma
Background CD4+ T-cell lymphocytopenia and immune dysfunction are factors that drive the onset and persistence of Kaposi sarcoma (KS) in people with (PWH) and without HIV. Standard chemotherapy agents for KS can contribute to increasing CD4+ T cell lymphocytopenia. IL-7 is a cytokine that is essential in T-cell development, proliferation and homeostasis. In PWH, IL-7… Continue reading Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma
Impact of hepatic steatosis on the efficacy of antiviral treatment for chronic hepatitis B and the establishment of predictive model: a cohort study
Metabolic dysfunction-associated steatotic disease (MASLD) and chronic hepatitis B (CHB) are prevalent liver disorders. Ongoing discussions investigate the impact of MASLD on the therapeutic outcomes of CHB. Continue reading on BioMed Central
An Extremely Successful Vaccine Story
by Gertrud U. Rey One of the most noteworthy advances in biomedical science is the vaccine for human papillomavirus (HPV). It has significantly changed the diagnostic and prognostic landscape in the field of cervical cancer. Cervical cancer is the fourth most common cancer in women globally, and it is a particular problem in low-income countries… Continue reading An Extremely Successful Vaccine Story
YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350
Despite its range of disease associations, Epstein-Barr virus (EBV) treatments or vaccines are lacking. Joyce et al. determined EBV gp350 structures complexed with either its human receptor, CR2, or virus-neutralizing antibodies (nAbs), thus illustrating structural convergence of viral receptor and nAbs and offering insights for vaccines and therapeutics for EBV.