AI SummaryThe content discusses a Phase 3 trial called VANCE, which examines the use of a combination of gemcitabine, carboplatin, and Epstein-Barr virus-specific autologous cytotoxic T lymphocytes in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M NPC). The study aims to determine if this chemo-immunotherapy strategy is more effective and improves quality of life compared… Continue reading Gemcitabine, carboplatin, and Epstein Barr virus-specific autologous cytotoxic T lymphocytes for recurrent or metastatic nasopharyngeal carcinoma: VANCE, an international randomized Phase 3 trial
Tag: Oncogenic Viruses
[News] Continued suboptimal HPV vaccine coverage in the USA
AI SummaryThe analysis by the US CDC showed that improvements in routine coverage of the HPV vaccine in the USA have stalled since the COVID-19 pandemic. The study looked at data from 2023, which revealed that only 61.4% of adolescents aged 13-17 were up to date with the full HPV vaccine schedule, a slight decrease… Continue reading [News] Continued suboptimal HPV vaccine coverage in the USA
An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection
AI SummaryThis article explores the role of the circadian clock in regulating liver physiology and disease in humans. Using male human liver chimeric mice, the study identifies rhythmically expressed genes in human hepatocytes, including transcription factors, chromatin modifiers, and enzymes. It also shows that hepatitis C virus infection perturbs the liver transcriptome, affecting the rhythmic… Continue reading An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection
Human papillomavirus 16 replication converts SAMHD1 into a homologous recombination factor and promotes its recruitment to replicating viral DNA
AI SummaryThis article discusses how the replication of Human papillomavirus 16 (HPV16) leads to the conversion of SAMHD1 into a homologous recombination factor, which then gets recruited to replicating viral DNA. This process plays a role in the replication of the virus and could potentially be targeted for therapeutic purposes.
Attenuated effector T cells are linked to control of chronic HBV infection
AI SummaryThis study focuses on hepatitis B virus (HBV)-specific CD8+ T cells and their role in chronic HBV infection. The research reveals a subset of effector CD8+ T cells that are attenuated but contribute to viral control during chronic infection. These findings suggest potential immunotherapeutic strategies for managing chronic HBV infection.Abstract Hepatitis B virus (HBV)-specific… Continue reading Attenuated effector T cells are linked to control of chronic HBV infection
The hidden strength of CD8+ T cells in chronic hepatitis B
AI SummaryThe article discusses the identification of a distinct subset of CD8+ T cells in chronic hepatitis B infection that retain cytotoxic functions and are linked to viral control. This discovery sheds light on the hidden strength of CD8+ T cells in combating chronic hepatitis B.A distinct subset of attenuated CD8+ T cells that retain… Continue reading The hidden strength of CD8+ T cells in chronic hepatitis B
A retrospective study revealing complex viral diversity and a substantial burden of HPV infection in SARS-CoV-2 positive individuals, Sierra Leone
AI SummaryThis article discusses a retrospective study conducted in Sierra Leone, revealing a high burden of human papillomavirus (HPV) infection in individuals who tested positive for SARS-CoV-2. The study highlights the importance of sequencing technology in disease control and outbreak response, despite challenges such as resource limitations. The findings suggest a complex viral diversity among… Continue reading A retrospective study revealing complex viral diversity and a substantial burden of HPV infection in SARS-CoV-2 positive individuals, Sierra Leone
[News] Peru advances towards universal health care for patients with cancer
On July 29, 2024, the International Atomic Energy Agency (IAEA) issued a statement praising Peru’s advances towards delivering universal health care for patients with cancer. The IAEA stated that nuclear medicine and radiotherapy services in Peru were being decentralised from Lima, the capital city, and that the country had extended coverage of the human papillomavirus… Continue reading [News] Peru advances towards universal health care for patients with cancer
New vaccine against cervical cancer combines prophylactic and therapeutic activity
AI SummaryThe article discusses a new vaccine against cancer-causing human papillomaviruses (HPV) that combines prophylactic and therapeutic activity. This vaccine is cost-effective, protects against multiple HPV types, and triggers immune responses against infected cells. It aims to increase HPV vaccination rates, especially in developing countries.A vaccine against cancer-causing human papillomaviruses (HPV) is intended to help… Continue reading New vaccine against cervical cancer combines prophylactic and therapeutic activity
Uncommon high distribution of HPV-16, HPV-54, and HPV-56 in female referred to a laboratory in Karaj, Iran: indications of a paradigm shift in HPV genotypes?
AI SummaryThe text discusses the high distribution of HPV-16, HPV-54, and HPV-56 in female patients referred to a laboratory in Karaj, Iran. This suggests a potential shift in the common HPV genotypes in the region. HPV is a common sexually transmitted infection, and understanding prevalent genotypes is crucial for effective prevention and treatment strategies. The… Continue reading Uncommon high distribution of HPV-16, HPV-54, and HPV-56 in female referred to a laboratory in Karaj, Iran: indications of a paradigm shift in HPV genotypes?