Science Immunology, Volume 10, Issue 104, February 2025.
Tag: Oncogenic Viruses
Breakthrough discovery unveils potential treatment for hepatitis B
In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, research led by Memorial Sloan Kettering Cancer Center (MSK), Weill Cornell Medicine and The Rockefeller University identified a vulnerability that opens the door to new treatments. The team successfully disrupted the… Continue reading Breakthrough discovery unveils potential treatment for hepatitis B
Digging into a decades-old hepatitis B mystery suggests a new potential treatment
In their effort to answer a decades-old biological question about how the hepatitis B virus (HBV) is able to establish infection of liver cells, researchers have identified a vulnerability that opens the door to new treatments.
Pyrazolo[3,4-d]pyrimidine-based neplanocin analogues identified as potential de novo pharmacophores for dual-target HBV inhibition
The discovery of selective and potent inhibitors through de novo pathways is essential to combat drug resistance in chronic hepatitis B (CHB) infections. Recent studies have highlighted that neplanocin A (NepA) derivatives are biologically selective inhibitors of the hepatitis B virus (HBV). In this study, we designed, synthesized, and evaluated various pyrazolo[3,4-d]pyrimidine-based NepA analogues (4a–h)… Continue reading Pyrazolo[3,4-d]pyrimidine-based neplanocin analogues identified as potential de novo pharmacophores for dual-target HBV inhibition
Novel Combination Immunotherapy and Clinical Activity in Patients With HPV-Associated Cancers
This nonrandomized clinical trial examines the clinical activity and adverse events of a novel combination treatment for advanced human papillomavirus–associated cancers.
Genotypic analysis of human papillomavirus in cervical exfoliated cells from women in Zigong
This study investigated the human papillomavirus (HPV) infection status among women in Zigong from January 2016 to August 2024 and provides a comprehensive statistical analysis of HPV infection characteristics… Continue reading on BioMed Central
Long-term inhibition of Hepatitis B virus gene expression by a primary microrna expressing ancestral adeno-associated viral vector
Current treatments for chronic infection with the hepatitis B virus (HBV) rarely cure carriers from the disease. Previously reported use of serotype 8 adeno-associated viral (AAV8) vectors to deliver expressio… Continue reading on BioMed Central
TWiV 1193: HPV or not to B
TWiV reviews a facility accident that killed monkeys, new bird blu genotype found in Nevada dairy cattle, Argentina plans to leave WHO, yellow fever on the rise, dynamics of HPV infections in women, and Epstein-Barr virus protein targets B cell receptor for degradation. Hosts: Vincent Racaniello, Alan Dove, and Angela Mingarelli Click arrow to playDownload TWiV… Continue reading TWiV 1193: HPV or not to B
Speculum exams unnecessary for HPV screening
Researchers have demonstrated that self-sampling is just as effective as speculum-based testing for HPV detection.
Gene therapy shows clinical benefit in patients with a debilitating disorder caused by HPV
An NCI clinical trial showed that an experimental gene therapy called PRGN-2012 may be an effective treatment for recurrent respiratory papillomatosis, which is caused by HPV 6 and HPV 11.