Tag: Nucleic Acid Biochemistry
Top advances of the year: Myeloproliferative neoplasms
Abstract The rapid pace of drug development in hematology has led to multiple approvals for myelofibrosis (MF) and polycythemia vera (PV) in recent years. Moreover, there are many innovative agents and combinations being explored for myeloproliferative neoplasms (MPNs). In the past year, there have been several advances in MF, PV, and essential thrombocythemia. In MF,… Continue reading Top advances of the year: Myeloproliferative neoplasms
Top advances of the year: Myeloproliferative neoplasms
Abstract The rapid pace of drug development in hematology has led to multiple approvals for myelofibrosis (MF) and polycythemia vera (PV) in recent years. Moreover, there are many innovative agents and combinations being explored for myeloproliferative neoplasms (MPNs). In the past year, there have been several advances in MF, PV, and essential thrombocythemia. In MF,… Continue reading Top advances of the year: Myeloproliferative neoplasms
The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R) instead of the exonically encoded GluA2(Q). Reduced Q/R site editing infcr…
Characterization of mismatch‐repair (MMR)/microsatellite instability (MSI)‐discordant endometrial cancers
AI SummaryThe study found that testing for mismatch-repair (MMR) deficiency in endometrial cancer can yield differing results and that tumors with mixed MMR findings may have more aggressive characteristics and a higher risk of spreading cancer. These findings suggest that reporting MMR testing only as intact or deficient without considering subclonal and heterogeneous staining may… Continue reading Characterization of mismatch‐repair (MMR)/microsatellite instability (MSI)‐discordant endometrial cancers
Characterization of mismatch‐repair (MMR)/microsatellite instability (MSI)‐discordant endometrial cancers
Abstract Background Mismatch-repair (MMR)/microsatellite instability (MSI) status has therapeutic implications in endometrial cancer (EC). The authors evaluated the concordance of testing and factors contributing to MMR expression heterogeneity. Methods Six hundred sixty-six ECs were characterized using immunohistochemistry (IHC), MSI testing, and mut-L homolog 1 (MLH1) methylation. Select samples underwent whole-transcriptome analysis and next-generation sequencing. MMR… Continue reading Characterization of mismatch‐repair (MMR)/microsatellite instability (MSI)‐discordant endometrial cancers
Post-COVID-19 epigenetic signatures
AI SummarySevere SARS-CoV-2 infection causes long-lasting changes in hematopoiesis. The study examines the effects of COVID-19 on epigenetic states and hematopoiesis over time. Differences in chromatin accessibility and transcriptional profiles are found in monocytes and HSPCs from COVID-19 patients compared to healthy controls. The study also explores the differential responses to tocilizumab in patients with… Continue reading Post-COVID-19 epigenetic signatures
Climate change and epigenetic biomarkers in allergic and airway diseases
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New insights to enhance treatment and diagnosis of blood cancer
AI SummaryA study has found that NSD2 and its target PKC-alpha play a role in making t(4;14) multiple myeloma more aggressive and resistant to treatment.A ground-breaking study has revealed crucial insights into the role of the histone methyltransferase NSD2 and its epigenetic target PKC-alpha in causing t(4;14) translocated multiple myeloma (MM), a high-risk subtype of… Continue reading New insights to enhance treatment and diagnosis of blood cancer
Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons
AI SummaryCullin 3 (CUL3) has been associated with schizophrenia and autism spectrum disorder, but its function in the dopamine (DA) system is not well understood. Researchers have found that CUL3 is critical for the function of DA neurons in male mice, and its deficiency results in hyperactivity, memory deficits, increased sensitivity to psychostimulants, and enhanced… Continue reading Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons