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Tag: Nucleic Acid Biochemistry
New insights to enhance treatment and diagnosis of blood cancer
AI SummaryA study has found that NSD2 and its target PKC-alpha play a role in making t(4;14) multiple myeloma more aggressive and resistant to treatment.A ground-breaking study has revealed crucial insights into the role of the histone methyltransferase NSD2 and its epigenetic target PKC-alpha in causing t(4;14) translocated multiple myeloma (MM), a high-risk subtype of… Continue reading New insights to enhance treatment and diagnosis of blood cancer
Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons
AI SummaryCullin 3 (CUL3) has been associated with schizophrenia and autism spectrum disorder, but its function in the dopamine (DA) system is not well understood. Researchers have found that CUL3 is critical for the function of DA neurons in male mice, and its deficiency results in hyperactivity, memory deficits, increased sensitivity to psychostimulants, and enhanced… Continue reading Deficiency of Cullin 3, a Protein Encoded by a Schizophrenia and Autism Risk Gene, Impairs Behaviors by Enhancing the Excitability of Ventral Tegmental Area (VTA) DA Neurons
Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
AI SummaryScientists from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), The Picower Institute for Learning and Memory, and The Broad Institute of MIT and Harvard have created a molecular atlas of human brain vasculature and its changes in Alzheimer’s disease (AD) across six brain regions. The researchers characterized over 22,514 vascular cells from different… Continue reading Atlas of human brain blood vessels highlights changes in Alzheimer’s disease
From labs to the streets, experts work to defuse childhood threats to mental health
AI SummaryThreats to child mental health, such as poverty, abuse, and pollution, were discussed by experts at a symposium at MIT, who stressed the importance of science and research in addressing these issues. The speakers highlighted various mechanisms that connect early life experiences to mental health problems, as well as interventions and programs aimed at… Continue reading From labs to the streets, experts work to defuse childhood threats to mental health