Viruses with double-stranded (ds) DNA genomes in the realm Duplodnaviria share a conserved structural gene module but show a broad range of variation in their repertoires of DNA replication proteins. Some of the … Continue reading on BioMed Central
Tag: Nucleic Acid Biochemistry
Regulation viral RNA transcription and replication by higher-order RNA structures within the nsp1 coding region of MERS coronavirus
AI SummaryThis study explores the role of higher-order RNA stem-loop structures within the nsp1 coding region of the Middle East respiratory syndrome coronavirus (MERS-CoV) in regulating viral RNA transcription and replication. Specific structures, such as SL5B and SL5C, were found to be essential for transcription, while SL5D mediated the synthesis of positive-strand genomic RNA. In… Continue reading Regulation viral RNA transcription and replication by higher-order RNA structures within the nsp1 coding region of MERS coronavirus
Breakthrough research unveils retroelement-based aging biomarkers
AI SummaryThis research highlights the discovery of DNA markers associated with retroelements, which are remnants of ancient viral genetic material in our genes that can act as highly accurate epigenetic clocks predicting chronological age. Retroelements are found to impact gene regulation, gene expression, genomic stability, and the trajectory of human diseases. The study suggests that… Continue reading Breakthrough research unveils retroelement-based aging biomarkers
BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses
The BCG vaccine for tuberculosis protects against non-mycobacterial infections, but the mechanisms are unclear. Sun et al. found that BCG alters gene expression and chromatin accessibility in hematopoietic stem and progenitor cells (HSPCs), predicting cytokine secretion in peripheral blood mononuclear cells. This research highlights BCG’s lasting, multimodal effects on HSPCs and the regulation of innate immune responses.
DNA-DISK: Automated end-to-end data storage via enzymatic single-nucleotide DNA synthesis and sequencing on digital microfluidics
Comprehensive genomic profiling of infiltrative follicular variant of papillary thyroid carcinoma
AI SummaryThe study aimed to characterize the genetic alterations of infiltrative follicular variant of papillary thyroid carcinoma (IFVPTC) through whole-exome sequencing. The results revealed that endogenous processes dominated the genome shaping, with BRAF V600E being a common trunk mutation. Subcloning analysis showed multiple coexisting clones in most samples, while somatic copy number alterations (sCNAs) highlighted… Continue reading Comprehensive genomic profiling of infiltrative follicular variant of papillary thyroid carcinoma
Comprehensive genomic profiling of infiltrative follicular variant of papillary thyroid carcinoma
AI SummaryThis study focused on comprehensive genomic profiling of infiltrative follicular variant of papillary thyroid carcinoma (IFVPTC). Key findings include the dominance of endogenous processes in shaping IFVPTC’s genome, identification of BRAF V600E as a significantly mutated gene, and the presence of multiple coexisting clones in most samples. Human leukocyte antigen C (HLA-C) was significantly… Continue reading Comprehensive genomic profiling of infiltrative follicular variant of papillary thyroid carcinoma
[ASAP] Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors
AI SummaryThis article discusses the discovery of gem-Dimethyl-hydroxymethylpyridine derivatives as potent non-nucleoside RSV polymerase inhibitors. The compounds identified show promise in inhibiting the polymerase enzyme of respiratory syncytial virus (RSV), which could lead to the development of new antiviral drugs. This research is significant in the field of virology and drug development for RSV infections.