A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new study.
Tag: Nucleic Acid Biochemistry
[ASAP] Discovery of a 2′-α-Fluoro-2′-β-C-(fluoromethyl) Purine Nucleotide Prodrug as a Potential Oral Anti-SARS-CoV-2 Agent
Experts Forecast Cancer Research and Treatment Advances in 2025
Every new year brings excitement and anticipation for what might happen over the next 12 months. So, what’s in store for 2025 that could change the way we diagnose and treat cancer? What first-in-class therapeutics could offer new life-saving options to patients? What scientific discovery will have everyone talking? In 2024, we saw the approval… Continue reading Experts Forecast Cancer Research and Treatment Advances in 2025
Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer’s Disease
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with profound global impact. While genome-wide association studies (GWAS) have revealed genomic variants linked to AD, their translational impact has been limited due to challenges in interpreting the identified genetic associations. To address this challenge, we have devised a novel approach termed transcription factor-wide association studies (TF-WAS).… Continue reading Transcription Factor-Wide Association Studies to Identify Functional SNPs in Alzheimer’s Disease
Past interactions of T cells with antigens shape CAR T cell responses
CAR T cells are engineered from a heterogeneous pool of T cells. This study shows that CAR T cells are epigenetically imprinted by the previous antigen exposure of the original T cell, which affects subsequent functional characteristics. These epigenetic differences can be used to identify genes that can be manipulated to modify function. This is… Continue reading Past interactions of T cells with antigens shape CAR T cell responses
Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion
Background Although tumor necrosis factor receptor 2 (TNFR2) has been recognized as an attractive next-generation candidate target for cancer immunotherapy, the factors that regulate the gene expression and their mechanistic effects on tumor-infiltrating regulatory T cells (Treg cells) remain poorly understood. Methods Single-cell RNA sequencing analysis was employed to analyze the phenotypic and functional differences… Continue reading Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion
Microglial CD2AP deficiency exerts protection in an Alzheimer’s disease model of amyloidosis
The CD2-associated protein (CD2AP) was initially identified in peripheral immune cells and regulates cytoskeleton and protein trafficking. Single nucleotide polymorphisms (SNPs) in the CD2AP gene have been associ…
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis
Science Immunology, Volume 9, Issue 102, December 2024.