Tag: Nucleic Acid Biochemistry

Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

AI SummaryThis study explores the epigenetic regulation of PD-1, a key negative regulator of CD8+ T cell activation highly expressed by exhausted T cells in cancer and chronic viral infection. By deleting an exhaustion-specific PD-1 enhancer, researchers observed optimized T cell function in a mouse model of chronic infection, leading to improved control of viral… Continue reading Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control

Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Correction to: Nature Immunology https://doi.org/10.1038/s41590-022-01290-3, published online 24 August 2022. In the version of this article initially published, due to an error during figure assembly, the image shown in the top-right WT mice, PAR cells, panel of Fig. 4d was a duplicate of the lower-left image in the CD4–/–CD8–/– mice, CD44L cells, panel. The figure… Continue reading Author Correction: Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

Trained innate immunity: concept, nomenclature and future perspectives

AI SummaryThis article discusses the concept of trained innate immunity, which refers to the enhanced responsiveness of innate immune cells following exposure to certain stimuli. The nomenclature of this phenomenon is explored, as well as its potential future perspectives in the field of immunology. The article likely delves into the mechanisms behind trained innate immunity,… Continue reading Trained innate immunity: concept, nomenclature and future perspectives

[ASAP] Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy

AI SummaryThe title suggests that researchers have discovered new inhibitors for DOT1L R231Q, a non-nucleoside enzyme involved in cancer. These inhibitors have improved pharmacokinetic properties, meaning they are more efficiently absorbed, distributed, metabolized, and excreted by the body. They also show anti-lung cancer efficacy, indicating they may be effective in treating lung cancer. The findings… Continue reading [ASAP] Discovery of Novel Non-nucleoside DOT1LR231Q Inhibitors with Improved Pharmacokinetic Properties and Anti-lung Cancer Efficacy

Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation

AI SummaryThe article discusses how tumor cells in emerging cancers alter their gene expression to evade immune control, a process known as immunoediting. The study found that this immunoevasion could be reversed by using a DNA methyltransferase inhibitor. This research sheds light on the importance of epigenetic regulation in tumor progression and immune recognition.Tumor cells… Continue reading Emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation

The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male–But Not Female–Rats to Enhance Short-Term Memory

AI SummaryThe study explores the interaction between the lysine acetyltransferase PCAF and estrogen receptor alpha (ERα) in the hippocampus of male rats in enhancing short-term memory (STM). The research indicates that PCAF, known for its role in long-term memory (LTM) through epigenetic processes, also influences STM possibly through nongenomic ER activity. The interaction was specific… Continue reading The Lysine Acetyltransferase PCAF Functionally Interacts with Estrogen Receptor Alpha in the Hippocampus of Gonadally Intact Male–But Not Female–Rats to Enhance Short-Term Memory

Keep calm and carry H3K27me1 off

AI SummaryThis article discusses a study that found stress-susceptible mice have increased levels of H3K27me1 in nucleus accumbens neurons due to the SUZ12 VEFS domain. This strengthens the connection between certain epigenetic changes and long-lasting stress-induced social, emotional, and cognitive alterations.In this issue of Neuron, Torres-Berrío et al. show that stress-susceptible mice exhibit elevated H3K27me1 levels… Continue reading Keep calm and carry H3K27me1 off

[ASAP] Kappa Opioid Receptor Activation Induces Epigenetic Silencing of Brain-Derived Neurotropic Factor via HDAC5 in Depression

AI SummaryThis article discusses how the activation of kappa opioid receptors can lead to the epigenetic silencing of brain-derived neurotropic factor (BDNF) through HDAC5 in depression. This research has implications for understanding the molecular mechanisms involved in depression and may lead to the development of new treatment approaches targeting these pathways.