Tag: Neurotransmission and Signaling

Finding some stability in adaptable brains

AI SummaryThe content discusses the balance in the brain between stability and flexibility, focusing on individual neurons and synapses in the sensory cortex. Pyramidal neurons have both stable and flexible synapses, with some synapses losing their flexibility by adulthood. The study reveals that stable synapses in a specific region of these neurons have unique properties… Continue reading Finding some stability in adaptable brains

[ASAP] Synthesis and Evaluation of 18F-Labeled Phenylpiperazine-like Dopamine D3 Receptor Radioligands for Positron Emission Tomography Imaging

AI SummaryThis article discusses the synthesis and evaluation of 18F-labeled phenylpiperazine-like dopamine D3 receptor radioligands for use in positron emission tomography (PET) imaging. The research focuses on developing radioligands that can accurately target and visualize dopamine D3 receptors in the brain. This has implications for studying neurological disorders and drug development. The study evaluates the… Continue reading [ASAP] Synthesis and Evaluation of 18F-Labeled Phenylpiperazine-like Dopamine D3 Receptor Radioligands for Positron Emission Tomography Imaging

Amyloid-{beta} Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling

AI SummaryThis research investigates how amyloid-β affects NMDA receptors and dendritic spine loss, potentially impairing learning and memory in Alzheimer’s disease. The study shows that amyloid-β engages AKAP-CaN signaling through mGluR1 activation, leading to changes in NMDA receptor function and dendritic spine stability. This highlights a new way in which amyloid-β disrupts synaptic function.Neuronal excitatory… Continue reading Amyloid-{beta} Causes NMDA Receptor Dysfunction and Dendritic Spine Loss through mGluR1 and AKAP150-Anchored Calcineurin Signaling

Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing

AI SummaryThe content discusses the discovery of heterogeneity in slow synaptic transmission at parallel fiber synapses to Purkinje cells in the mouse cerebellum. Unlike uniform fast synaptic transmission, the properties of slow synaptic transmission varied significantly across different lobules, leading to surprising heterogeneity in the timing of Purkinje cell firing patterns. Depending on the location… Continue reading Heterogeneity in Slow Synaptic Transmission Diversifies Purkinje Cell Timing

Fluorescent probe reveals action mechanism of serotonin in depression

AI SummaryThe content discusses a new fluorescent probe designed by a Chinese team to study the action mechanism of serotonin in depression. The probe is highly sensitive and selective towards serotonin, allowing for better imaging processes in cell and animal models. This research is crucial for understanding the role of serotonin in depression and could… Continue reading Fluorescent probe reveals action mechanism of serotonin in depression

[ASAP] Kinetic Properties of Glutamate Carboxypeptidase II Partially Purified from Leukodystrophy Patient’s Serum

AI SummaryThis article explores the kinetic properties of Glutamate Carboxypeptidase II that has been partially purified from the serum of patients with leukodystrophy. The study aims to investigate the enzyme’s activity and potential implications for the disease. By understanding the kinetic properties of this enzyme, researchers hope to gain insights into the underlying mechanisms of… Continue reading [ASAP] Kinetic Properties of Glutamate Carboxypeptidase II Partially Purified from Leukodystrophy Patient’s Serum

Finding some stability in adaptable brains

AI SummaryIn a study conducted by MIT’s McGovern Institute, researchers like neuroscientist Mark Harnett investigate how individual neurons in the brain’s sensory cortex can maintain stability while also being adaptable. They discovered that some synapses on pyramidal neurons lose flexibility early in life, allowing for a combination of stable and flexible synapses to interpret visual… Continue reading Finding some stability in adaptable brains

Cracking and Packing Information about the Features of Expected Rewards in the Orbitofrontal Cortex

AI SummaryThis article discusses how the orbitofrontal cortex (OFC) processes information about expected rewards in decision-making scenarios. The study found that OFC neurons in male rats integrate details about reward timing and flavor, firing differentially based on these features. When reward features are correlated, the OFC tends to combine them into single constructs, while when… Continue reading Cracking and Packing Information about the Features of Expected Rewards in the Orbitofrontal Cortex

Association between Inhibitory-Excitatory Balance and Brain Activity Response during Cognitive Flexibility in Young and Older Individuals

AI SummaryThe study focuses on the association between inhibitory-excitatory balance in the left inferior frontal cortex (IFC) and left inferior parietal lobule (IPL) and brain activity response during cognitive flexibility in young and older individuals. Results indicate differences in metabolic mechanisms underlying cognitive flexibility in the two age groups, with implications for executive functioning and… Continue reading Association between Inhibitory-Excitatory Balance and Brain Activity Response during Cognitive Flexibility in Young and Older Individuals